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Descriptor English: Tensins
Descriptor Spanish: Tensinas
Descriptor tensinas
Entry term(s) tensina
Scope note: Familia de proteínas multidominio de los microfilamentos que unen FILAMENTOS DE ACTINA e INTEGRINAS en las ADHESIONES FOCALES. Suelen constar de un dominio N-terminal homólogo a la FOSFOTIROSINA FOSFATASA, un DOMINIO C2, regiones centrales únicas ricas en PROLINA, ALANINA, GLICINA y SERINA, un DOMINIO SH2 y una región C-terminal de unión a fosfotirosina. Están implicadas en la MIGRACIÓN CELULAR, ADHESIÓN CELULAR, TRANSDUCCIÓN DE SEÑAL y reorganización del CITOESQUELETO.
Descriptor Portuguese: Tensinas
Descriptor French: Tensines
Entry term(s): Tensin
Tree number(s): D05.750.078.730.719
D12.776.220.525.719
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000070876
Scope note: A family of multidomain microfilament proteins that bind ACTIN FILAMENTS and INTEGRINS at FOCAL ADHESIONS. They generally consist of an N-terminal domain with homology to PHOSPHOTYROSINE PHOSPHATASE, a C2 DOMAIN; unique central regions rich in PROLINE; ALANINE; GLYCINE; and SERINE; an SH2 DOMAIN; and a C-terminal phosphotyrosine-binding region. They are involved in CELL MIGRATION; CELL ADHESION; SIGNAL TRANSDUCTION; and reorganization of the CYTOSKELETON.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2017; TENSINS was indexed under MICROFILAMENT PROTEINS (1992-2016)
History Note: 2017 (1992)
DeCS ID: 56436
Unique ID: D000070876
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/02/26
Tensins - Preferred
Concept UI M0201606
Scope note A family of multidomain microfilament proteins that bind ACTIN FILAMENTS and INTEGRINS at FOCAL ADHESIONS. They generally consist of an N-terminal domain with homology to PHOSPHOTYROSINE PHOSPHATASE, a C2 DOMAIN; unique central regions rich in PROLINE; ALANINE; GLYCINE; and SERINE; an SH2 DOMAIN; and a C-terminal phosphotyrosine-binding region. They are involved in CELL MIGRATION; CELL ADHESION; SIGNAL TRANSDUCTION; and reorganization of the CYTOSKELETON.
Preferred term Tensins
Entry term(s) Tensin



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