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Descriptor English: Gelsolin
Descriptor Spanish: Gelsolina
Descriptor gelsolina
Scope note: Proteína de 90 kDa producida por macrófagos que escinde los filamentos de ACTINA y forma una cubierta en el extremo del filamento recién expuesto. La gelsolina es activada por los iones de CALCIO y participa en la agregación y desagregación de la actina, incrementando así la motilidad de algunas CÉLULAS.
Descriptor Portuguese: Gelsolina
Descriptor French: Gelsoline
Entry term(s): Gelsolin Protein
Serum Actin Inhibitory Protein
Tree number(s): D05.750.078.730.350
D12.644.360.372.437
D12.776.157.125.412.437
D12.776.220.525.350
D12.776.476.387.437
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D018260
Scope note: A 90-kDa protein produced by macrophages that severs ACTIN filaments and forms a cap on the newly exposed filament end. Gelsolin is activated by CALCIUM ions and participates in the assembly and disassembly of actin, thereby increasing the motility of some CELLS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 1994; GELSOLIN was indexed under CALCIUM-BINDING PROTEINS and MICROFILAMENT PROTEINS 1980-1993; SERUM ACTIN IHIBITORY PROTEIN was indexed under MICROFILAMENT PROTEINS 1988-2005, & under MUSCLE PROTEINS & PROTEINS 1986-1987
History Note: 1994(1980)
DeCS ID: 31448
Unique ID: D018260
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1994/01/01
Date of Entry: 1993/06/03
Revision Date: 2017/06/30
Gelsolin - Preferred
Concept UI M0027489
Scope note A 90-kDa protein produced by macrophages that severs ACTIN filaments and forms a cap on the newly exposed filament end. Gelsolin is activated by CALCIUM ions and participates in the assembly and disassembly of actin, thereby increasing the motility of some CELLS.
Preferred term Gelsolin
Entry term(s) Gelsolin Protein
Serum Actin Inhibitory Protein



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