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Descriptor English: Calponins
Descriptor Spanish: Calponinas
Descriptor calponinas
Entry term(s) calponina
proteínas de la familia de las calponinas
Scope note: Familia de proteínas que se unen a la actina principalmente en el músculo liso. Las calponinas incluyen la alfa-calponina (h1 o básica), que es la más abundante, la beta-calponina, la calponina neutra (calponina h2), la calponina ácida y la transgelina (SM22). Los miembros de la familia de las calponinas tienen un dominio de homología de calponina (CH) aminoterminal único y múltiples repeticiones similares a la calponina carboxiterminales de 23 aminoácidos de longitud denominadas CLICK-23. Las calponinas participan en la modulación de la contracción del músculo liso mediante la unión a ACTINAS (actinas F y G), CALMODULINA y tropomiosina.
Descriptor Portuguese: Calponinas
Descriptor French: Without translation
Entry term(s): Calponin
Calponin Family Proteins
Tree number(s): D05.750.078.730.266
D12.776.157.125.123
D12.776.210.500.187
D12.776.220.525.268
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000096985
Scope note: A family of actin binding proteins mostly in smooth muscle. Calponins include most abundant alpha-calponin (h1 or basic); beta-calponin; neutral calponin (h2 calponin); acidic calponin, SM22, and transgelin. Calponin family members have N-terminal single Calponin Homology (CH) domain and multiple C-terminus 23-amino acids long calponin-like repeats called CLICK-23. Calponins participate in modulation of smooth muscle contraction by binding to ACTINS (F- and G-Actins), CALMODULIN and TROPOMYSIN.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Microfilament Proteins (1990-2023)
Public MeSH Note: 2024
History Note: 2024
DeCS ID: 60542
Unique ID: D000096985
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2024/01/01
Date of Entry: 2023/07/26
Revision Date: 2023/06/07
Calponins - Preferred
Concept UI M000762830
Scope note A family of actin binding proteins mostly in smooth muscle. Calponins include most abundant alpha-calponin (h1 or basic); beta-calponin; neutral calponin (h2 calponin); acidic calponin, SM22, and transgelin. Calponin family members have N-terminal single Calponin Homology (CH) domain and multiple C-terminus 23-amino acids long calponin-like repeats called CLICK-23. Calponins participate in modulation of smooth muscle contraction by binding to ACTINS (F- and G-Actins), CALMODULIN and TROPOMYSIN.
Preferred term Calponins
Entry term(s) Calponin
Calponin Family Proteins



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