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Descriptor English: Myristoylated Alanine-Rich C Kinase Substrate
Descriptor Spanish: Sustrato de la Proteína Quinasa C Rico en Alanina Miristoilada
Descriptor Portuguese: Substrato Quinase C Rico em Alanina Miristoilada
Descriptor French: Protéine myristoylée riche en alanine et substrat de la kinase C
Entry term(s): ACAMP-81
MARCKS Protein
Myristoylated Alanine Rich C Kinase Substrate
Tree number(s): D05.750.078.730.556
D12.644.360.537
D12.776.157.142.375
D12.776.157.687.496
D12.776.220.525.556
D12.776.476.539
D12.776.543.637
D12.776.660.720.496
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000076250
Scope note: A membrane and ACTIN CYTOSKELETON associated, N-terminal myristoylated protein that binds CALMODULIN and is a prominent substrate for PROTEIN KINASE C. Both phosphorylation and poly(ADP)-ribosylation inhibit its F-ACTIN crosslinking activity; phosphorylation also causes MARCKS to relocate from the membrane to cytoplasm.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: 125267-21-2
Public MeSH Note: 2018; MYRISTOYLATED ALANINE-RICH C KINASE SUBSTRATE was indexed under MEMBRANE PROTEINS and INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS 1989-2017
History Note: 2018 (1989)
DeCS ID: 56988
Unique ID: D000076250
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29
Myristoylated Alanine-Rich C Kinase Substrate - Preferred
Concept UI M0166716
Scope note A membrane and ACTIN CYTOSKELETON associated, N-terminal myristoylated protein that binds CALMODULIN and is a prominent substrate for PROTEIN KINASE C. Both phosphorylation and poly(ADP)-ribosylation inhibit its F-ACTIN crosslinking activity; phosphorylation also causes MARCKS to relocate from the membrane to cytoplasm.
Preferred term Myristoylated Alanine-Rich C Kinase Substrate
Entry term(s) ACAMP-81
MARCKS Protein
Myristoylated Alanine Rich C Kinase Substrate



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