| Descriptor English: | Myristoylated Alanine-Rich C Kinase Substrate | ||||||
| Descriptor Spanish: |
Sustrato de la Proteína Quinasa C Rico en Alanina Miristoilada
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| Descriptor Portuguese: | Substrato Quinase C Rico em Alanina Miristoilada | ||||||
| Descriptor French: | Protéine myristoylée riche en alanine et substrat de la kinase C | ||||||
| Entry term(s): |
ACAMP-81 MARCKS Protein Myristoylated Alanine Rich C Kinase Substrate |
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| Tree number(s): |
D05.750.078.730.556 D12.644.360.537 D12.776.157.142.375 D12.776.157.687.496 D12.776.220.525.556 D12.776.476.539 D12.776.543.637 D12.776.660.720.496 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000076250 | ||||||
| Scope note: | A membrane and ACTIN CYTOSKELETON associated, N-terminal myristoylated protein that binds CALMODULIN and is a prominent substrate for PROTEIN KINASE C. Both phosphorylation and poly(ADP)-ribosylation inhibit its F-ACTIN crosslinking activity; phosphorylation also causes MARCKS to relocate from the membrane to cytoplasm. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | 125267-21-2 | ||||||
| Public MeSH Note: | 2018; MYRISTOYLATED ALANINE-RICH C KINASE SUBSTRATE was indexed under MEMBRANE PROTEINS and INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS 1989-2017 |
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| History Note: | 2018 (1989) |
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| DeCS ID: | 56988 | ||||||
| Unique ID: | D000076250 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2018/01/01 | ||||||
| Date of Entry: | 2017/07/11 | ||||||
| Revision Date: | 2017/06/29 |
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CHEMICALS AND DRUGS
Macromolecular Substances [D05]Macromolecular Substances -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Myristoylated Alanine-Rich C Kinase Substrate
- Preferred
| Concept UI |
M0166716 |
| Scope note | A membrane and ACTIN CYTOSKELETON associated, N-terminal myristoylated protein that binds CALMODULIN and is a prominent substrate for PROTEIN KINASE C. Both phosphorylation and poly(ADP)-ribosylation inhibit its F-ACTIN crosslinking activity; phosphorylation also causes MARCKS to relocate from the membrane to cytoplasm. |
| Preferred term | Myristoylated Alanine-Rich C Kinase Substrate |
| Entry term(s) |
ACAMP-81 MARCKS Protein Myristoylated Alanine Rich C Kinase Substrate |
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