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Descriptor English: Omalizumab
Descriptor Spanish: Omalizumab
Descriptor omalizumab
Scope note: Un anti-IgE, un anticuerpo recombinante, humanizado monoclonal que se une específicamente al dominio C epsilon3 de INMUNOGLOBULINA E, el sitio de receptor de IgE de alta afinidad de unión. Se inhibe la unión de IgE a los MASTOCITOS y BASÓFILOS para reducir la gravedad de la respuesta alérgica y se utiliza en el tratamiento del ASMA alérgica persistente.
Descriptor Portuguese: Omalizumab
Descriptor French: Omalizumab
Entry term(s): Xolair
Tree number(s): D12.776.124.486.485.114.071.500
D12.776.124.486.485.114.224.060.844
D12.776.124.790.651.114.071.500
D12.776.124.790.651.114.224.060.844
D12.776.377.715.548.114.071.500
D12.776.377.715.548.114.224.200.844
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000069444
Scope note: An anti-IgE, recombinant, humanized monoclonal antibody which specifically binds to the C epsilon3 domain of IMMUNOGLOBULIN E, the site of high-affinity IgE receptor binding. It inhibits the binding of IgE to MAST CELLS and BASOPHILS to reduce the severity of the allergic response and is used in the management of persistent allergic ASTHMA.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Anti-Allergic Agents
Anti-Asthmatic Agents
Registry Number: 2P471X1Z11
CAS Type 1 Name: Immunoglobulin G, anti-(human immunoglobulin E Fc region)(human-mouse monoclonal E25 clone pSVIE26 gamma-chain), disulfide with human-mouse monoclonal E25 clone pSVIE26 kappa-chain, dimer
Public MeSH Note: 2016; OMALIZUMAB was indexed under ANTIBODIES, ANTI-IDIOTYPIC and ANTIBODIES, MONOCLONAL, HUMANIZED 2011-2015; and under ANTIBODIES, MONOCLONAL 2001-2011
History Note: 2016 (2001)
DeCS ID: 55972
Unique ID: D000069444
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2016/01/01
Date of Entry: 2015/07/01
Revision Date: 2017/06/20
Omalizumab - Preferred
Concept UI M0387411
Scope note An anti-IgE, recombinant, humanized monoclonal antibody which specifically binds to the C epsilon3 domain of IMMUNOGLOBULIN E, the site of high-affinity IgE receptor binding. It inhibits the binding of IgE to MAST CELLS and BASOPHILS to reduce the severity of the allergic response and is used in the management of persistent allergic ASTHMA.
Preferred term Omalizumab
Xolair - Narrower
Concept UI M0446701
Preferred term Xolair



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