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Descriptor English: Denosumab
Descriptor Spanish: Denosumab
Descriptor denosumab
Scope note: Un anticuerpo monoclonal humanizado y un inhibidor del ligando RANK, que regula la diferenciación de OSTEOCLASTOS y la REMODELACIÓN ÓSEA. Se utiliza como CONSERVADORES de la DENSIDAD ÓSEA en el tratamiento de la OSTEOPOROSIS.
Descriptor Portuguese: Denosumab
Descriptor French: Dénosumab
Entry term(s): AMG 162
Prolia
Xgeva
Tree number(s): D12.776.124.486.485.114.224.060.782
D12.776.124.790.651.114.224.060.782
D12.776.377.715.548.114.224.200.782
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000069448
Scope note: A humanized monoclonal antibody and an inhibitor of the RANK LIGAND, which regulates OSTEOCLAST differentiation and bone remodeling. It is used as a BONE DENSITY CONSERVATION AGENT in the treatment of OSTEOPOROSIS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Bone Density Conservation Agents
Registry Number: 4EQZ6YO2HI
Public MeSH Note: 2016; DENOSUMAB was indexed under ANTIBODIES, MONOCLONAL, HUMANIZED 2012-2015; and under ANTIBODIES, MONOCLONAL 2004-2012
History Note: 2016 (2004)
Related: RANK Ligand MeSH
DeCS ID: 55976
Unique ID: D000069448
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2016/01/01
Date of Entry: 2015/07/01
Revision Date: 2017/06/20
Denosumab - Preferred
Concept UI M0493770
Scope note A humanized monoclonal antibody and an inhibitor of the RANK LIGAND, which regulates OSTEOCLAST differentiation and bone remodeling. It is used as a BONE DENSITY CONSERVATION AGENT in the treatment of OSTEOPOROSIS.
Preferred term Denosumab
Xgeva - Narrower
Concept UI M0554986
Preferred term Xgeva
AMG 162 - Narrower
Concept UI M0478464
Preferred term AMG 162
Prolia - Narrower
Concept UI M0555596
Preferred term Prolia



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