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Descriptor English: Syk Kinase
Descriptor Spanish: Quinasa Syk
Descriptor cinasa Syk
Entry term(s) quinasa Syk
tirosina cinasa del bazo
tirosina cinasa esplénica
tirosina quinasa Syk
tirosina quinasa del bazo
tirosina quinasa esplénica
tirosina quinasa lienal
Scope note: Tirosina quinasa no-receptor con dominio SH2 que regula la transducción descendente de señales de distintos receptores entre los cuales se encuentran los RECEPTORES DE ANTÍGENO DE LOS LINFOCITOS B. Actúa tanto en la INMUNIDAD INNATA como en la INMUNIDAD ADAPTATIVA y también media la señalización en la ADHESIÓN CELULAR, OSTEOGÉNESIS, ACTIVACIÓN PLAQUETARIA y desarrollo vascular.
Descriptor Portuguese: Quinase Syk
Descriptor French: Syk kinase
Entry term(s): Kinase, SYK Tyrosine
Kinase, Spleen Tyrosine
Kinase, Syk
SYK Tyrosine Kinase
Spleen Tyrosine Kinase
Tyrosine Kinase, SYK
Tyrosine Kinase, Spleen
Tree number(s): D08.811.913.696.620.682.725.650
D12.776.476.568.650
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000072377
Scope note: An SH2 domain-containing non-receptor tyrosine kinase that regulates signal transduction downstream of a variety of receptors including B-CELL ANTIGEN RECEPTORS. It functions in both INNATE IMMUNITY and ADAPTIVE IMMUNITY and also mediates signaling in CELL ADHESION; OSTEOGENESIS; PLATELET ACTIVATION; and vascular development.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.10.2
Public MeSH Note: 2017; SYK KINASE was indexed under PROTEIN-TYROSINE KINASES and INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS 2006-2016; and under ENZYME PRECURSORS 1992-2006
History Note: 2017 (1992)
Related: src Homology Domains MeSH
DeCS ID: 56517
Unique ID: D000072377
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/05/27
Syk Kinase - Preferred
Concept UI M0195193
Scope note An SH2 domain-containing non-receptor tyrosine kinase that regulates signal transduction downstream of a variety of receptors including B-CELL ANTIGEN RECEPTORS. It functions in both INNATE IMMUNITY and ADAPTIVE IMMUNITY and also mediates signaling in CELL ADHESION; OSTEOGENESIS; PLATELET ACTIVATION; and vascular development.
Preferred term Syk Kinase
Entry term(s) Kinase, SYK Tyrosine
Kinase, Spleen Tyrosine
Kinase, Syk
SYK Tyrosine Kinase
Spleen Tyrosine Kinase
Tyrosine Kinase, SYK
Tyrosine Kinase, Spleen



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