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Descriptor English: | Pyrin | ||||||
Descriptor Spanish: |
Pirina
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Descriptor Portuguese: | Pirina | ||||||
Descriptor French: | Pyrine | ||||||
Entry term(s): |
Marénostrine Protéine MEFV Protéine TRIM20 Protéine de la fièvre méditerranéenne |
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Tree number(s): |
D12.776.220.909 D12.776.934.750 |
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RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000071198 | ||||||
Scope note: | A tripartite motif protein that consists of an N-terminal pyrin domain, a central coiled-coil region and B-box type ZINC FINGER, and C-terminal regions that mediate homotrimerization and interactions with other proteins (the B30.2/SPRY DOMAIN). It is expressed primarily by mature GRANULOCYTES and associates with the cytoskeleton in the perinuclear area as well as AUTOPHAGOSOMES, where it co-ordinates the assembly of AUTOPHAGY-RELATED PROTEINS and degradation of INFLAMMASOME components. It functions in INNATE IMMUNITY and INFLAMMATION; mutations in the Pyrin protein (MEFV) gene are associated with FAMILIAL MEDITERRANEAN FEVER. |
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Allowable Qualifiers: |
AD administration et posologie AE effets indésirables AG agonistes AI antagonistes et inhibiteurs AN analyse BI biosynthèse BL sang CF liquide cérébrospinal CH composition chimique CL classification CS synthèse chimique DE effets des médicaments et des substances chimiques DF déficit EC économie GE génétique HI histoire IM immunologie IP isolement et purification ME métabolisme PD pharmacologie PH physiologie PK pharmacocinétique PO intoxication RE effets des radiations SD ressources et distribution ST normes TO toxicité TU usage thérapeutique UL ultrastructure UR urine |
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Related: |
Domaine pyrine
MeSH | ||||||
DeCS ID: | 56595 | ||||||
Unique ID: | D000071198 | ||||||
Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
Date Established: | 2017/01/01 | ||||||
Date of Entry: | 2016/07/08 | ||||||
Revision Date: | 2016/07/05 |
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PRODUITS CHIMIQUES ET PHARMACEUTIQUES
Acides aminés, peptides et protéines [D12]Acides aminés, peptides et protéines -
PRODUITS CHIMIQUES ET PHARMACEUTIQUES
Acides aminés, peptides et protéines [D12]Acides aminés, peptides et protéines
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Pyrine
- Preferred
Concept UI |
M0281114 |
Preferred term | Pyrine |
Entry term(s) |
Marénostrine Protéine MEFV Protéine TRIM20 Protéine de la fièvre méditerranéenne |
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