| Descriptor English: | 5-Aminolevulinate Synthetase | ||||||
| Descriptor Spanish: |
5-Aminolevulinato Sintetasa
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| Descriptor Portuguese: | 5-Aminolevulinato Sintetase | ||||||
| Descriptor French: | 5-Aminolevulinate synthetase | ||||||
| Entry term(s): |
5 Aminolevulinate Synthase 5 Aminolevulinate Synthetase 5-Aminolevulinate Synthase Acid Synthetase, Aminolevulinic Acid Synthetase, delta-Aminolevulinic Aminolevulinic Acid Synthetase Synthase, 5-Aminolevulinate Synthase, delta-Aminolevulinate Synthetase, 5-Aminolevulinate Synthetase, Aminolevulinic Acid Synthetase, delta-Aminolevulinic Acid delta Aminolevulinate Synthase delta Aminolevulinic Acid Synthetase delta-Aminolevulinate Synthase delta-Aminolevulinic Acid Synthetase |
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| Tree number(s): |
D08.811.913.050.276 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000624 | ||||||
| Scope note: | An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.3.1.37 | ||||||
| CAS Type 1 Name: | Succinyl-CoA:glycine C-Succinyltransferase (decarboxylating) | ||||||
| Previous Indexing: |
Acyltransferases (1966-1971) |
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| Public MeSH Note: | 98; see AMINOLEVULINIC ACID SYNTHETASE 1972-97 |
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| History Note: | 98(72) |
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| DeCS ID: | 634 | ||||||
| Unique ID: | D000624 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1973/01/01 | ||||||
| Date of Entry: | 1999/01/01 | ||||||
| Revision Date: | 2007/07/09 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes
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5-Aminolevulinate Synthetase
- Preferred
| Concept UI |
M0000954 |
| Scope note | An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37. |
| Preferred term | 5-Aminolevulinate Synthetase |
| Entry term(s) |
5 Aminolevulinate Synthase 5 Aminolevulinate Synthetase 5-Aminolevulinate Synthase Acid Synthetase, Aminolevulinic Acid Synthetase, delta-Aminolevulinic Aminolevulinic Acid Synthetase Synthase, 5-Aminolevulinate Synthase, delta-Aminolevulinate Synthetase, 5-Aminolevulinate Synthetase, Aminolevulinic Acid Synthetase, delta-Aminolevulinic Acid delta Aminolevulinate Synthase delta Aminolevulinic Acid Synthetase delta-Aminolevulinate Synthase delta-Aminolevulinic Acid Synthetase |
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