| Descriptor English: | Phosphatidylcholine-Sterol O-Acyltransferase | ||||||
| Descriptor Spanish: |
Fosfatidilcolina-Esterol O-Aciltransferasa
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| Descriptor Portuguese: | Fosfatidilcolina-Esterol O-Aciltransferase | ||||||
| Descriptor French: | Phosphatidylcholine-Sterol O-Acyltransferase | ||||||
| Entry term(s): |
Acyltransferase, Lecithin Acyltransferase, Lecithin Cholesterol Acyltransferase, Phosophatidylcholine-Sterol Cholesterol Acyltransferase, Lecithin Cholesterol Ester Lysolecithin Acyltransferase Lecithin Acyltransferase Lecithin Cholesterol Acyltransferase O-Acyltransferase, Phosphatidylcholine-Sterol Phosophatidylcholine Sterol Acyltransferase Phosophatidylcholine-Sterol Acyltransferase Phosphatidylcholine Sterol O Acyltransferase |
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| Tree number(s): |
D08.811.913.050.625 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D007862 | ||||||
| Scope note: | An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Entry Combination: |
deficiency:Lecithin Cholesterol Acyltransferase Deficiency
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| Registry Number: | EC 2.3.1.43 | ||||||
| CAS Type 1 Name: | Phosphatidylcholine:sterol O-acyltransferase | ||||||
| Previous Indexing: |
Acyltransferases (1966-1974) Cholesterol (1966-1974) Phosphatidylcholines (1966-1974) |
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| Public MeSH Note: | 98; see LECITHIN ACYLTRANSFERASE 1978-97; see ACYLTRANSFERASES 1975-77 |
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| History Note: | 98(75) |
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| DeCS ID: | 8040 | ||||||
| Unique ID: | D007862 | ||||||
| NLM Classification: | QU 141 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1978/01/01 | ||||||
| Date of Entry: | 1974/11/11 | ||||||
| Revision Date: | 2016/07/01 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes
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Phosphatidylcholine-Sterol O-Acyltransferase
- Preferred
| Concept UI |
M0012276 |
| Scope note | An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma. |
| Preferred term | Phosphatidylcholine-Sterol O-Acyltransferase |
| Entry term(s) |
Acyltransferase, Lecithin Acyltransferase, Lecithin Cholesterol Acyltransferase, Phosophatidylcholine-Sterol Cholesterol Acyltransferase, Lecithin Cholesterol Ester Lysolecithin Acyltransferase Lecithin Acyltransferase Lecithin Cholesterol Acyltransferase O-Acyltransferase, Phosphatidylcholine-Sterol Phosophatidylcholine Sterol Acyltransferase Phosophatidylcholine-Sterol Acyltransferase Phosphatidylcholine Sterol O Acyltransferase |
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