| Descriptor English: | Hydroxymethylglutaryl-CoA Synthase | ||||||
| Descriptor Spanish: |
Hidroximetilglutaril-CoA Sintasa
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| Descriptor Portuguese: | Hidroximetilglutaril-CoA Sintase | ||||||
| Descriptor French: | Hydroxymethylglutaryl-coA synthase | ||||||
| Entry term(s): |
3 hydroxy 3 methylglutaryl coenzyme A synthase 3-hydroxy-3-methylglutaryl-coenzyme A synthase A synthase, 3-hydroxy-3-methylglutaryl-coenzyme CoA Synthase, HMG HMG CoA Synthase HMG-CoA synthase Hydroxymethylglutaryl CoA Synthase Synthase, HMG CoA Synthase, Hydroxymethylglutaryl-CoA synthase, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, HMG-CoA |
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| Tree number(s): |
D08.811.913.050.612 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D006904 | ||||||
| Scope note: | An enzyme that catalyzes the synthesis of hydroxymethylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA. This is a key enzyme in steroid biosynthesis. This enzyme was formerly listed as EC 4.1.3.5. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.3.3.10 | ||||||
| CAS Type 1 Name: | (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) | ||||||
| Previous Indexing: |
Coenzyme A (1973-1974) Glutarates (1973-1974) Ketoacid-Lyases (1973-1974) |
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| Public MeSH Note: | 1991; HMG-COA SYNTHASE was indexed under HYDROXYMETHYLGLUTARYL-COA SYNTHASE 2005-2008, & under COENZYME A LIGASES 2001-2005 |
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| History Note: | 1991(1975); |
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| Entry Version: | HMG COA SYNTHASE |
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| DeCS ID: | 7075 | ||||||
| Unique ID: | D006904 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1991/01/01 | ||||||
| Date of Entry: | 1974/11/19 | ||||||
| Revision Date: | 2019/04/29 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes
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Hydroxymethylglutaryl-CoA Synthase
- Preferred
| Concept UI |
M0010773 |
| Scope note | An enzyme that catalyzes the synthesis of hydroxymethylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA. This is a key enzyme in steroid biosynthesis. This enzyme was formerly listed as EC 4.1.3.5. |
| Preferred term | Hydroxymethylglutaryl-CoA Synthase |
| Entry term(s) |
3 hydroxy 3 methylglutaryl coenzyme A synthase 3-hydroxy-3-methylglutaryl-coenzyme A synthase A synthase, 3-hydroxy-3-methylglutaryl-coenzyme CoA Synthase, HMG HMG CoA Synthase HMG-CoA synthase Hydroxymethylglutaryl CoA Synthase Synthase, HMG CoA Synthase, Hydroxymethylglutaryl-CoA synthase, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, HMG-CoA |
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