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Descriptor English: 2-Isopropylmalate Synthase
Descriptor Spanish: 2-Isopropilmalato Sintasa
Descriptor 2-isopropilmalato sintasa
Scope note: Enzima que cataliza el primer paso de la vía biosintética de la LEUCINA, formando isopropil malato a partir de acetil-CoA y ácido alfa-cetoisovalérico. Anteriormente se clasificaba como EC 4.1.3.12.
Descriptor Portuguese: 2-Isopropilmalato Sintase
Descriptor French: 2-Isopropylmalate synthase
Entry term(s): 2 Isopropylmalate Synthase
Synthase, 2-Isopropylmalate
Synthase, alpha-Isopropylmalate
alpha Isopropylmalate Synthase
alpha-Isopropylmalate Synthase
Tree number(s): D08.811.913.050.614
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015079
Scope note: An enzyme that catalyzes the first step in the biosynthetic pathway to LEUCINE, forming isopropyl malate from acetyl-CoA and alpha-ketoisovaleric acid. This enzyme was formerly listed as EC 4.1.3.12.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.3.3.13
CAS Type 1 Name: 3-Carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating)
Previous Indexing: Ketoacid-Lyases (1973-1974)
Ketoacids (1973-1974)
Malates (1973-1974)
Public MeSH Note: 91; was see under KETOACID-LYASES 1975-90
History Note: 91(75); was see under KETOACID-LYASES 1975-90
DeCS ID: 7712
Unique ID: D015079
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2005/06/30
2-Isopropylmalate Synthase - Preferred
Concept UI M0023192
Scope note An enzyme that catalyzes the first step in the biosynthetic pathway to LEUCINE, forming isopropyl malate from acetyl-CoA and alpha-ketoisovaleric acid. This enzyme was formerly listed as EC 4.1.3.12.
Preferred term 2-Isopropylmalate Synthase
Entry term(s) 2 Isopropylmalate Synthase
Synthase, 2-Isopropylmalate
Synthase, alpha-Isopropylmalate
alpha Isopropylmalate Synthase
alpha-Isopropylmalate Synthase



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