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Descriptor English: Insulysin
Descriptor Spanish: Insulisina
Descriptor Portuguese: Insulisina
Descriptor French: Insulinase
Entry term(s): Enzyme, Insulin-Degrading
Insulin Degrading Enzyme
Insulin Protease
Insulin Proteinase
Insulin-Degrading Enzyme
Insulinase
Protease, Insulin
Proteinase, Insulin
Tree number(s): D08.811.277.656.300.480.300
D08.811.277.656.675.374.300
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007339
Scope note: An enzyme the catalyzes the degradation of insulin, glucagon and other polypeptides. It is inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not phosphoramidon. (Eur J Biochem 1994;223:1-5) EC 3.4.24.56.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.24.56
Public MeSH Note: 97; was INSULINASE 1963-96 (see under PEPTIDE HYDROLASES 1975-90, see under PEPTIDE PEPTIDOHYDROLASES 1963-74)
Online Note: search ENDOPEPTIDASES 1966-74
History Note: 97; was INSULINASE 1963-96 (see under PEPTIDE HYDROLASES 1975-90, see under ENDOPEPTIDASES 1963-74)
DeCS ID: 7509
Unique ID: D007339
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1999/01/01
Revision Date: 2003/07/09
Insulysin - Preferred
Concept UI M0011443
Scope note An enzyme the catalyzes the degradation of insulin, glucagon and other polypeptides. It is inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not phosphoramidon. (Eur J Biochem 1994;223:1-5) EC 3.4.24.56.
Preferred term Insulysin
Entry term(s) Enzyme, Insulin-Degrading
Insulin Degrading Enzyme
Insulin Protease
Insulin Proteinase
Insulin-Degrading Enzyme
Insulinase
Protease, Insulin
Proteinase, Insulin



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