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Descriptor English: | Proinsulin | ||||
Descriptor Spanish: |
Proinsulina
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Descriptor Portuguese: | Proinsulina | ||||
Descriptor French: | Proinsuline | ||||
Entry term(s): |
Pro-insuline |
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Tree number(s): |
D06.472.699.587.200.500 D12.644.548.586.200.500 D12.776.811.706 |
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RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D011384 | ||||
Scope note: | A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts. |
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Allowable Qualifiers: |
AD administration et posologie AE effets indésirables AG agonistes AI antagonistes et inhibiteurs AN analyse BI biosynthèse BL sang CF liquide cérébrospinal CH composition chimique CL classification CS synthèse chimique DE effets des médicaments et des substances chimiques DF déficit EC économie GE génétique HI histoire IM immunologie IP isolement et purification ME métabolisme PD pharmacologie PH physiologie PK pharmacocinétique PO intoxication RE effets des radiations SD ressources et distribution ST normes TO toxicité TU usage thérapeutique UL ultrastructure UR urine |
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Registry Number: | 9035-68-1 | ||||
CAS Type 1 Name: | Proinsulin | ||||
DeCS ID: | 11816 | ||||
Unique ID: | D011384 | ||||
NLM Classification: | WK 820 | ||||
Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||
Date Established: | 1972/01/01 | ||||
Date of Entry: | 1999/01/01 | ||||
Revision Date: | 2011/06/24 |
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PRODUITS CHIMIQUES ET PHARMACEUTIQUES
Hormones, substituts d'hormones et antagonistes d'hormones [D06]Hormones, substituts d'hormones et antagonistes d'hormones -
PRODUITS CHIMIQUES ET PHARMACEUTIQUES
Acides aminés, peptides et protéines [D12]Acides aminés, peptides et protéines -
PRODUITS CHIMIQUES ET PHARMACEUTIQUES
Acides aminés, peptides et protéines [D12]Acides aminés, peptides et protéines
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