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Descriptor in English: Kininogens
Descriptor in Spanish: Quininógenos
Descriptor in Portuguese: Cininogênios
Descriptor in French: Kininogènes
Entry term(s): Cystatins, Kininogen
Kininogen
Kininogen Cystatins
Prekinins
Prokinins
T Kininogen
T-Kininogen
Thiostatin
Tree number(s): D12.644.276.812.654
D12.776.124.125.635
D12.776.467.812.654
D12.776.811.420
D23.119.630
D23.469.050.375.425
D23.529.812.654
Scope note: Endogenous peptides present in most body fluids. Certain enzymes convert them to active KININS which are involved in inflammation, blood clotting, complement reactions, etc. Kininogens belong to the cystatin superfamily. They are cysteine proteinase inhibitors. HIGH-MOLECULAR-WEIGHT KININOGEN; (HMWK); is split by plasma kallikrein to produce BRADYKININ. LOW-MOLECULAR-WEIGHT KININOGEN; (LMWK); is split by tissue kallikrein to produce KALLIDIN.
Annotation: cysteine proteinase inhib; /drug eff /physiol permitted
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
History Note: 74(72)
DeCS UI: 28118
Descriptor UI: D007704
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2006/07/05
Kininogens - Preferred
Concept UI M0012050
Scope note Endogenous peptides present in most body fluids. Certain enzymes convert them to active KININS which are involved in inflammation, blood clotting, complement reactions, etc. Kininogens belong to the cystatin superfamily. They are cysteine proteinase inhibitors. HIGH-MOLECULAR-WEIGHT KININOGEN; (HMWK); is split by plasma kallikrein to produce BRADYKININ. LOW-MOLECULAR-WEIGHT KININOGEN; (LMWK); is split by tissue kallikrein to produce KALLIDIN.
Preferred term Kininogens
Entry term(s) Cystatins, Kininogen
Kininogen Cystatins
Prekinins
Prokinins
T-Kininogen - Narrower
Concept UI M0012051
Preferred term T-Kininogen
Entry term(s) T Kininogen
Thiostatin - Narrower
Concept UI M0012053
Preferred term Thiostatin
Kininogen - Narrower
Concept UI M0012052
Preferred term Kininogen



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