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Descriptor English: Amyloid beta-Protein Precursor
Descriptor Spanish: Precursor de Proteína beta-Amiloide
Descriptor Portuguese: Precursor de Proteína beta-Amiloide
Descriptor French: Précurseur de la protéine bêta-amyloïde
Entry term(s): Amyloid A4 Protein Precursor
Amyloid Protein Precursor
Amyloid beta Precursor Protein
Amyloid beta Protein Precursor
Nexin 2, Protease
Nexin II, Protease
Protease Nexin 2
Protease Nexin II
beta Amyloid Protein Precursor
beta-Amyloid Protein Precursor
beta-Protein Precursor, Amyloid
Tree number(s): D12.776.049.407.249
D12.776.543.039
D12.776.645.468.500
D12.776.811.050
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016564
Scope note: A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Amyloid (1988-1991)
Protein Precursors (1988-1991)
Public MeSH Note: 92; AMYLOID BETA-PROTEIN PRECURSOR was indexed under AMYLOID BETA-PROTEIN 1990-91 and AMYLOID & PROTEIN PRECURSORS 1988-91; AMYLOID A4 PROTEIN PRECURSOR was indexed under AMYLOID BETA-PROTEIN PRECURSOR 1993-94, AMYLOID BETA-PROTEIN 1991-92, PROTEIN PRECURSORS 1987-92, & AMYLOID 1987-90
Online Note: use AMYLOID BETA-PROTEIN PRECURSOR (NM) to search AMYLOID BETA-PROTEIN PRECURSOR 1988-91 & AMYLOID A4 PROTEIN PRECURSOR 1987-94
History Note: 92; was AMYLOID BETA PROTEIN PRECURSOR (NM) 1988-91; AMYLOID A4 PROTEIN PRECURSOR was NM 1987-94
Entry Version: ABPP
DeCS ID: 30268
Unique ID: D016564
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1992/01/01
Date of Entry: 1991/07/12
Revision Date: 2013/07/09
Amyloid beta-Protein Precursor - Preferred
Concept UI M0025265
Scope note A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.
Preferred term Amyloid beta-Protein Precursor
Entry term(s) Amyloid A4 Protein Precursor
Amyloid Protein Precursor
Amyloid beta Precursor Protein
Amyloid beta Protein Precursor
Nexin 2, Protease
Nexin II, Protease
Protease Nexin 2
Protease Nexin II
beta Amyloid Protein Precursor
beta-Amyloid Protein Precursor
beta-Protein Precursor, Amyloid



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