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Descriptor English: Angiotensinogen
Descriptor Spanish: Angiotensinógeno
Descriptor Portuguese: Angiotensinogênio
Descriptor French: Angiotensinogène
Entry term(s): Hypertensinogen
Proangiotensin
Renin Substrate
Renin Substrate Tetradecapeptide
Renin-Substrate
SERPINA8
Serpin A8
Tetradecapeptide, Renin Substrate
Tree number(s): D12.644.456.073.070
D12.644.861.020
D12.776.811.070
D12.776.872.020
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000808
Scope note: An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Serine Proteinase Inhibitors
Registry Number: 11002-13-4
CAS Type 1 Name: Angiotensinogen (protein renin substrate)
Previous Indexing: Alpha Globulins (1968-1974)
Angiotensin II (1968-1974)
Protein Precursors (1971-1974)
Public MeSH Note: 87; was see under ANGIOTENSINS 1975-86
History Note: 87(75); was see under ANGIOTENSINS 1975-86
DeCS ID: 27913
Unique ID: D000808
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1987/01/01
Date of Entry: 1974/11/19
Revision Date: 2020/06/09
Angiotensinogen - Preferred
Concept UI M0001208
Scope note An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM.
Preferred term Angiotensinogen
Entry term(s) Hypertensinogen
Proangiotensin
Renin Substrate
Renin-Substrate
SERPINA8
Serpin A8
Renin Substrate Tetradecapeptide - Narrower
Concept UI M0001209
Scope note A synthetic or processed 14-amino acid peptide that is used to measure RENIN activities.
Preferred term Renin Substrate Tetradecapeptide
Entry term(s) Tetradecapeptide, Renin Substrate



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