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Descriptor English: Integrins
Descriptor Spanish: Integrinas
Descriptor integrinas
Entry term(s) integrina
Scope note: Familia de glicoproteínas transmembrana (GLICOPROTEÍNAS DE MEMBRANA), constituidas por heterodímeros no covalentes. Interactúan con una gran variedad de ligandos, incluidas las PROTEÍNAS DE LA MATRIZ EXTRACELULAR, las PROTEÍNAS DEL SISTEMA DEL COMPLEMENTO y otras células, mientras que sus dominios intracelulares interactúan con el CITOESQUELETO. Se han identificado al menos tres familias de integrinas: los RECEPTORES DE CITOADHESINA, los RECEPTORES DE ADHESIÓN LEUCOCITARIA y los RECEPTORES DE ANTÍGENOS MUY TARDÍOS. Cada familia tiene una subunidad beta común (CADENAS BETA DE INTEGRINAS) combinada con una o más subunidades alfa diferentes (CADENAS ALFA DE INTEGRINAS). Estos receptores participan en la adhesión célula-matriz y célula-célula en muchos procesos fisiológicos importantes, como el desarrollo embrionario, la HEMOSTASIA, la TROMBOSIS, la CICATRIZACIÓN DE HERIDAS, los mecanismos de defensa inmunitaria y no inmunitaria y la transformación oncogénica.
Descriptor Portuguese: Integrinas
Descriptor French: Intégrines
Entry term(s): Integrin
Tree number(s): D12.776.543.750.705.408
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016023
Scope note: A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors (RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
Annotation: prefer specifics
Allowable Qualifiers: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Previous Indexing: Glycoproteins (1966-1987)
Membrane Glycoproteins (1988-1989)
Receptors, Endogenous Substances (1973-1989)
Receptors, Immunologic (1980-1989)
Public MeSH Note: 90
History Note: 90
Related: Cell Adhesion Molecules MeSH
DeCS ID: 24746
Unique ID: D016023
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/07/07
Revision Date: 2020/05/27
Integrins - Preferred
Concept UI M0024497
Scope note A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors (RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
Preferred term Integrins
Entry term(s) Integrin



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