DeCS

Descriptor English:

Receptors, Thrombin

Descriptor Spanish:

Receptores de Trombina

Spanish from Spain

Descriptor

receptores de trombina

Scope note:

Familia de los receptores activados de la proteinasa, que son específicos para la TROMBINA. Se encuentran principalmente en las PLAQUETAS y en las CÉLULAS ENDOTELIALES. La activación de los receptores de trombina se realiza por la acción proteolítica de la TROMBINA, que desdobla el péptido N-terminal del receptor para revelar un nuevo péptido N-terminal que es un ligando críptico del receptor. Los receptores señalan mediante las PROTEÍNAS DE UNIÓN A GTP HETEROTRIMÉRICAS. Los pequeños péptidos sintéticos que contienen la secuencia peptídica N-terminal no enmascarada pueden activar también el receptor en ausencia de actividad proteolítica.

Descriptor Portuguese:

Receptores de Trombina

Descriptor French:

Récepteurs à la thrombine

Entry term(s):

Peptide, TRAP
Receptor, Thrombin
TRAP Peptide
Thrombin Receptor
Thrombin Receptor Activating Peptide Ligand
Thrombin Receptor Activating Peptides
Thrombin Receptor Activator Peptide
Thrombin Receptors

Tree number(s):

D09.400.430.890.625.800
D12.776.395.550.625.800
D12.776.543.550.625.800
D12.776.543.750.695.875
D12.776.543.750.705.675.892
D12.776.543.750.750.850
D12.776.543.750.792.500

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D018179

Scope note:

A family of proteinase-activated receptors that are specific for THROMBIN. They are found primarily on PLATELETS and on ENDOTHELIAL CELLS. Activation of thrombin receptors occurs through the proteolytic action of THROMBIN, which cleaves the N-terminal peptide from the receptor to reveal a new N-terminal peptide that is a cryptic ligand for the receptor. The receptors signal through HETEROTRIMERIC GTP-BINDING PROTEINS. Small synthetic peptides that contain the unmasked N-terminal peptide sequence can also activate the receptor in the absence of proteolytic activity.

Allowable Qualifiers:

AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure

Concept UI	M0027406
Scope note	A family of proteinase-activated receptors that are specific for THROMBIN. They are found primarily on PLATELETS and on ENDOTHELIAL CELLS. Activation of thrombin receptors occurs through the proteolytic action of THROMBIN, which cleaves the N-terminal peptide from the receptor to reveal a new N-terminal peptide that is a cryptic ligand for the receptor. The receptors signal through HETEROTRIMERIC GTP-BINDING PROTEINS. Small synthetic peptides that contain the unmasked N-terminal peptide sequence can also activate the receptor in the absence of proteolytic activity.
Preferred term	Receptors, Thrombin
Entry term(s)	Receptor, Thrombin Thrombin Receptor Thrombin Receptors

Concept UI	M0445097
Scope note	A cryptic peptide ligand contained within the N-terminal of the thrombin receptor.
Preferred term	Thrombin Receptor Activating Peptides
Entry term(s)	Peptide, TRAP TRAP Peptide Thrombin Receptor Activating Peptide Ligand Thrombin Receptor Activator Peptide

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