| Descriptor English: | CD59 Antigens | ||||||
| Descriptor Spanish: |
Antígenos CD59
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| Descriptor Portuguese: | Antígenos CD59 | ||||||
| Descriptor French: | Antigènes CD59 | ||||||
| Entry term(s): |
Antigens, CD59 CD59 Antigen HRF20 Homologous Restriction Factor 20 MACIF Membrane Attack Complex Inhibition Factor Membrane Inhibitor of Reactive Lysis Protectin |
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| Tree number(s): |
D09.400.430.890.448.140 D12.776.395.550.448.140 D12.776.543.484.500.140 D12.776.543.550.418.140 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D018957 | ||||||
| Scope note: | Small glycoproteins found on both hematopoietic and non-hematopoietic cells. CD59 restricts the cytolytic activity of homologous complement by binding to C8 and C9 and blocking the assembly of the membrane attack complex. (From Barclay et al., The Leukocyte Antigen FactsBook, 1993, p234) |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Pharm Action: |
Complement Inactivating Agents |
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| Previous Indexing: |
Antigens, CD (1990-1995) Antigens, Differentiation (1989-1991) Membrane Glycoproteins (1989-1995) |
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| Public MeSH Note: | 2018; see ANTIGENS, CD59 1996-2017 and CD59 ANTIGEN 1989-1995; CD59 ANTIGEN was indexed under ANTIGENS, CD 1990-1995; under MEMBRANE GLYCOPROTEINS 1989-1995; and under ANTIGENS, DIFFERENTIATION 1989-1991; MEMBRANE ATTACK COMPLEX INHIBITION FACTOR was indexed under PROTEINS 1992-1997 and under BLOOD PROTEINS 1990-1991; PROTECTIN was indexed under ION CHANNELS 1996-1999 |
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| History Note: | 2018 (1990); for PROTECTIN use CATIONIC PROTEIN, URATE-CALCIUM OXALATE STONE 1996-1999 |
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| DeCS ID: | 32839 | ||||||
| Unique ID: | D018957 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1996/01/01 | ||||||
| Date of Entry: | 1995/05/26 | ||||||
| Revision Date: | 2017/06/06 |
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CHEMICALS AND DRUGS
Carbohydrates [D09]Carbohydrates -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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CD59 Antigens
- Preferred
| Concept UI |
M0028327 |
| Scope note | Small glycoproteins found on both hematopoietic and non-hematopoietic cells. CD59 restricts the cytolytic activity of homologous complement by binding to C8 and C9 and blocking the assembly of the membrane attack complex. (From Barclay et al., The Leukocyte Antigen FactsBook, 1993, p234) |
| Preferred term | CD59 Antigens |
| Entry term(s) |
Antigens, CD59 CD59 Antigen HRF20 Homologous Restriction Factor 20 MACIF Membrane Attack Complex Inhibition Factor Membrane Inhibitor of Reactive Lysis Protectin |
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