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Descriptor English: Disintegrins
Descriptor Spanish: Desintegrinas
Descriptor Portuguese: Desintegrinas
Descriptor French: Désintégrines
Entry term(s): Disintegrin
Tree number(s): D12.644.138
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019483
Scope note: A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors.
Annotation: polypeptides from snake venom; platelet aggregation inhib
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Platelet Aggregation Inhibitors
Previous Indexing: Peptides (1992-1996)
Venoms (1992-1994)
Public MeSH Note: 97; DISINTEGRINS was indexed under PEPTIDES 1992-96 & VENOMS 1992-94
Online Note: use DISINTEGRINS (NM) to search DISINTEGRINS 1992-96
History Note: 97; was DISINTEGRINS (NM) 1992-96
DeCS ID: 33035
Unique ID: D019483
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1997/01/01
Date of Entry: 1996/06/10
Revision Date: 2020/05/27
Disintegrins - Preferred
Concept UI M0028974
Scope note A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors.
Preferred term Disintegrins
Entry term(s) Disintegrin



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