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Descriptor English: Proglucagon
Descriptor Spanish: Proglucagón
Descriptor proglucagón
Scope note: Polipéptido precursor común del GLUCAGÓN pancreático y de PÉPTIDOS SIMILARES AL GLUCAGÓN intestinal. El proglucagón es el segmento de 158 aminoácidos del preproglucagón sin la secuencia de señal N-terminal. El proglucagón se expresa en el PÁNCREAS, los INTESTINOS y el SISTEMA NERVIOSO CENTRAL. El procesamiento posterior a la traducción del proglucagón es específico de los tejidos y da lugar a numerosos péptidos bioactivos.
Descriptor Portuguese: Proglucagon
Descriptor French: Proglucagon
Entry term(s): Glucagon Precursor
Glucagon Precursors
Pre-Proglucagons
Preproglucagon
Preproglucagons
Pro Glucagon
Pro-Glucagon
Tree number(s): D06.472.317.680
D06.472.699.587.730
D12.644.548.586.730
D12.776.811.700
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D052336
Scope note: The common precursor polypeptide of pancreatic GLUCAGON and intestinal GLUCAGON-LIKE PEPTIDES. Proglucagon is the 158-amino acid segment of preproglucagon without the N-terminal signal sequence. Proglucagon is expressed in the PANCREAS; INTESTINES; and the CENTRAL NERVOUS SYSTEM. Posttranslational processing of proglucagon is tissue-specific yielding numerous bioactive peptides.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: 55963-74-1
Previous Indexing: Enteroglucagon (1982-2005)
Glucagon (1973-2005)
Public MeSH Note: 2007; see GLUCAGON PRECURSORS 2006; GLUCAGON PRECURSOR was indexed under PROGLUCAGON 2006-2007, PROTEIN PRECURSORS & GLUCAGON 1977-2005
History Note: 2007 (2006); for GLUCAGON PRECURSOR use GLUCAGON PRECURSOR (NM) 1977-2007
DeCS ID: 50566
Unique ID: D052336
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2018/07/05
Proglucagon - Preferred
Concept UI M0086289
Scope note The common precursor polypeptide of pancreatic GLUCAGON and intestinal GLUCAGON-LIKE PEPTIDES. Proglucagon is the 158-amino acid segment of preproglucagon without the N-terminal signal sequence. Proglucagon is expressed in the PANCREAS; INTESTINES; and the CENTRAL NERVOUS SYSTEM. Posttranslational processing of proglucagon is tissue-specific yielding numerous bioactive peptides.
Preferred term Proglucagon
Entry term(s) Pro Glucagon
Pro-Glucagon
Preproglucagon - Related but not broader or narrower
Concept UI M0097238
Preferred term Preproglucagon
Entry term(s) Pre-Proglucagons
Preproglucagons
Glucagon Precursors - Broader
Concept UI M0484570
Preferred term Glucagon Precursors
Entry term(s) Glucagon Precursor



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