| Descriptor English: | B7-2 Antigen | ||||||
| Descriptor Spanish: |
Antígeno B7-2
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| Descriptor Portuguese: | Antígeno B7-2 | ||||||
| Descriptor French: | Antigène CD86 | ||||||
| Entry term(s): |
Antigen, B7 2 Antigen, B7-2 Antigen, CD86 Antigens, CD86 B7 2 Antigen B7-2 Costimulatory Molecule B70 Costimulatory Molecule CD86 Antigen CD86 Antigens Costimulatory Molecule, B7-2 Costimulatory Molecule, B70 Early T Cell Costimulatory Molecule 1 |
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| Tree number(s): |
D12.776.465.500 D12.776.467.150.200 D12.776.543.095.200 D23.050.301.285.200 D23.529.168.200 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D051940 | ||||||
| Scope note: | A costimulatory ligand glycoprotein that contains a C2 and V-type IMMUNOGLOBULIN DOMAIN. It is expressed by ANTIGEN-PRESENTING CELLS and binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Public MeSH Note: | 2018; see ANTIGENS, CD86 2006-2017; B7-2 ANTIGEN was indexed under MEMBRANE GLYCOPROTEINS and ANTIGENS, CD 1996-2005; and under B-CELL ACTIVATION ANTIGEN 1993-1995 |
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| History Note: | 2018 (1993) |
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| Related: |
Immunoglobulin Domains
MeSH | ||||||
| DeCS ID: | 51076 | ||||||
| Unique ID: | D051940 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2006/01/01 | ||||||
| Date of Entry: | 2005/06/30 | ||||||
| Revision Date: | 2017/05/24 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Biological Factors [D23]Biological Factors -
CHEMICALS AND DRUGS
Biological Factors [D23]Biological Factors
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B7-2 Antigen
- Preferred
| Concept UI |
M0223248 |
| Scope note | A costimulatory ligand glycoprotein that contains a C2 and V-type IMMUNOGLOBULIN DOMAIN. It is expressed by ANTIGEN-PRESENTING CELLS and binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE. |
| Preferred term | B7-2 Antigen |
| Entry term(s) |
Antigen, B7 2 Antigen, B7-2 Antigen, CD86 Antigens, CD86 B7 2 Antigen B7-2 Costimulatory Molecule B70 Costimulatory Molecule CD86 Antigen CD86 Antigens Costimulatory Molecule, B7-2 Costimulatory Molecule, B70 Early T Cell Costimulatory Molecule 1 |
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