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Descriptor English: Caspase 8
Descriptor Spanish: Caspasa 8
Descriptor caspasa 8
Entry term(s) CASP8
proteasa Mch5
proteína FLICE
proteína MACH
Scope note: Cspasa con prodominio largo que contiene un dominio efector de muerte en su región prodominio. Interviene en la APOPTOSIS mediante la escisión y activación de CASPASAS EFECTORAS. La activación de esta enzima puede tener lugar a través de la interacción de su dominio efector de muerte N-terminal con PROTEÍNAS ADAPTADORAS DE SEÑALIZACIÓN DEL RECEPTOR DE DOMINIOS DE MUERTE.
Descriptor Portuguese: Caspase 8
Descriptor French: Caspase 8
Entry term(s): CAP4 Protease
Caspase-8
FLICE Protein
MACH Protein
Mch5 Protease
Pro Caspase 8
Pro-Caspase-8
Procaspase 8
Procaspase-8
Tree number(s): D08.811.277.656.262.500.126.550.800
D08.811.277.656.300.200.126.550.800
D12.776.157.057.018.037
D12.776.476.024.320.025
D12.776.476.075.405.550.800
D12.776.476.075.421.037
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053181
Scope note: A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Caspase Inhibitors
deficiency:Alstrom Syndrome
Registry Number: EC 3.4.22.-
Public MeSH Note: 2007; CASPASE 8 was indexed under CASPASES 1999-2006 & under CYSTEINE PROTEINASES 1997-1998
History Note: 2007(2000)
Related: Autoimmune Lymphoproliferative Syndrome MeSH
DeCS ID: 52227
Unique ID: D053181
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2017/05/24
Caspase 8 - Preferred
Concept UI M0283158
Scope note A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.
Preferred term Caspase 8
Entry term(s) CAP4 Protease
Caspase-8
FLICE Protein
MACH Protein
Mch5 Protease
Procaspase-8 - Narrower
Concept UI M0360985
Preferred term Procaspase-8
Entry term(s) Pro Caspase 8
Pro-Caspase-8
Procaspase 8



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