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Descriptor English: Nuclear Receptor Coactivators
Descriptor Spanish: Coactivadores de Receptor Nuclear
Descriptor coactivadores de receptores nucleares
Scope note: Proteínas que aumentan la expresión de los genes cuando se asocian con ligandos unidos a RECEPTORES NUCLEARES activados. Los coactivadores pueden actuar a través de un proceso enzimático que afecta a la tasa de transcripción o a la estructura de la cromatina. También pueden actuar como proteínas adaptadoras que aproximan los receptores nucleares a los complejos de transcripción. 
Descriptor Portuguese: Coativadores de Receptor Nuclear
Descriptor French: Coactivateurs de récepteurs nucléaires
Tree number(s): D12.644.360.024.314
D12.776.157.057.080
D12.776.476.024.394
D12.776.660.675
D12.776.930.617
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D056918
Scope note: Proteins that enhance gene expression when associated with ligand bound activated NUCLEAR RECEPTORS. The coactivators may act through an enzymatic process that affects the rate of transcription or the structure of chromatin. Alternatively nuclear receptor coactivators can function as adaptor proteins that bring nuclear receptors into close proximity with transcriptional complexes.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Transcription Factors (1991-2009)
Public MeSH Note: 2010
History Note: 2010
DeCS ID: 53620
Unique ID: D056918
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2016/03/30
Nuclear Receptor Coactivators - Preferred
Concept UI M0533377
Scope note Proteins that enhance gene expression when associated with ligand bound activated NUCLEAR RECEPTORS. The coactivators may act through an enzymatic process that affects the rate of transcription or the structure of chromatin. Alternatively nuclear receptor coactivators can function as adaptor proteins that bring nuclear receptors into close proximity with transcriptional complexes.
Preferred term Nuclear Receptor Coactivators



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