| Descriptor English: | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | ||||||
| Descriptor Spanish: |
Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma
| ||||||
| Descriptor Portuguese: | Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo | ||||||
| Descriptor French: | Coactivateur 1-alpha du récepteur gamma activé par les proliférateurs de peroxysomes | ||||||
| Entry term(s): |
PGC 1 alpha Protein PGC-1-alpha Protein PPARGC 1 alpha Protein PPARGC-1-alpha Protein PPARGC1a Protein Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 alpha |
||||||
| Tree number(s): |
D12.644.360.024.314.650 D12.776.157.057.080.650 D12.776.157.725.813.875 D12.776.476.024.394.650 D12.776.660.675.650 D12.776.664.962.813.875 D12.776.930.617.650 |
||||||
| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000071248 | ||||||
| Scope note: | A transcriptional co-activator for NUCLEAR RECEPTORS. It is characterized by an N-terminal LxxLL sequence, a region that interacts with PPAR GAMMA, and a C-terminal RNA RECOGNITION MOTIF. It increases expression of MITOCHONDRIAL UNCOUPLING PROTEIN to regulate genes involved in metabolic reprogramming in response to dietary restriction and the integration of CIRCADIAN RHYTHMS with ENERGY METABOLISM. |
||||||
| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
||||||
| Previous Indexing: |
Transcription Factors (2004-2016) |
||||||
| Public MeSH Note: | 2017 |
||||||
| History Note: | 2017 |
||||||
| DeCS ID: | 56537 | ||||||
| Unique ID: | D000071248 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2017/01/01 | ||||||
| Date of Entry: | 2016/07/08 | ||||||
| Revision Date: | 2016/03/30 |
-
-
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
|
|
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
- Preferred
| Concept UI |
M000613853 |
| Scope note | A transcriptional co-activator for NUCLEAR RECEPTORS. It is characterized by an N-terminal LxxLL sequence, a region that interacts with PPAR GAMMA, and a C-terminal RNA RECOGNITION MOTIF. It increases expression of MITOCHONDRIAL UNCOUPLING PROTEIN to regulate genes involved in metabolic reprogramming in response to dietary restriction and the integration of CIRCADIAN RHYTHMS with ENERGY METABOLISM. |
| Preferred term | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha |
| Entry term(s) |
PGC 1 alpha Protein PGC-1-alpha Protein PPARGC 1 alpha Protein PPARGC-1-alpha Protein PPARGC1a Protein Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 alpha |
We want your feedback on the new DeCS / MeSH website
We invite you to complete a survey that will take no more than 3 minutes.
Go to survey
