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Descriptor English: Mismatch Repair Endonuclease PMS2
Descriptor Spanish: Endonucleasa PMS2 de Reparación del Emparejamiento Incorrecto
Descriptor endonucleasa PMS2 de reparación del emparejamiento incorrecto
Entry term(s) incremento de segregación posmeiótica (S. cerevisiae) 2
incremento de segregación postmeiótica (S. cerevisiae) 2
proteína PMS-2
proteína PMS2
proteína de reparación del emparejamiento incorrecto, homólogo 2 de PMS1
Scope note: Proteína MutL componente del sistema de REPARACIÓN DEL EMPAREJAMIENTO INCORRECTO DEL ADN. Su actividad ENDONUCLEASA introduce ROTURAS DEL ADN DE CADENA SIMPLE lo que crea puntos de entrada para la exonucleasa EXO1 con el fin de extraer la cadena que contiene el error de apareamiento. También puede funcionar en la señalización del DAÑO DEL ADN.
Descriptor Portuguese: Endonuclease PMS2 de Reparo de Erro de Pareamento
Descriptor French: Mismatch repair endonuclease PMS2
Entry term(s): PMS 2 Protein
PMS-2 Protein
PMS1 Homolog 2, Mismatch Repair Protein
PMS2 Protein
Postmeiotic Segregation Increased S. cerevisiae 2
Postmeiotic Segregation Increased-S. cerevisiae-2
Tree number(s): D08.811.074.766.250
D08.811.277.040.025.215.250
D08.811.277.352.335.350.600
D12.776.260.540.250
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000070976
Scope note: A MutL protein and component of the DNA MISMATCH REPAIR system. Its ENDONUCLEASE activity introduces SINGLE-STRAND DNA BREAKS which create entry points for EXO1 exonuclease to remove the strand containing the mismatch. It may also function in DNA DAMAGE signaling.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.6.1.3
Previous Indexing: Adenosine Triphosphatases (2001-2016)
DNA Repair Enzymes (2001-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56466
Unique ID: D000070976
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/03/01
Mismatch Repair Endonuclease PMS2 - Preferred
Concept UI M000612774
Scope note A MutL protein and component of the DNA MISMATCH REPAIR system. Its ENDONUCLEASE activity introduces SINGLE-STRAND DNA BREAKS which create entry points for EXO1 exonuclease to remove the strand containing the mismatch. It may also function in DNA DAMAGE signaling.
Preferred term Mismatch Repair Endonuclease PMS2
Entry term(s) PMS 2 Protein
PMS-2 Protein
PMS1 Homolog 2, Mismatch Repair Protein
PMS2 Protein
Postmeiotic Segregation Increased S. cerevisiae 2
Postmeiotic Segregation Increased-S. cerevisiae-2



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