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Descriptor English: Mitochondrial Uncoupling Proteins
Descriptor Spanish: Proteínas Desacopladoras Mitocondriales
Descriptor proteínas desacopladoras mitocondriales
Entry term(s) UPC mitocondriales
UPCs mitocondriales
proteína desacopladora
proteínas desacopladoras
Scope note: Proteínas transportadoras de aniones mitocondriales que funcionan como dímeros y forman canales de protones en la MEMBRANA MITOCONDRIAL INTERNA que crean fugas de protones y desacoplan la FOSFORILACIÓN OXIDATIVA de la síntesis de ATP generando calor en lugar de ATP.
Descriptor Portuguese: Proteínas de Desacoplamento Mitocondrial
Descriptor French: Protéines de découplage mitochondrial
Entry term(s): Mitochondrial UCPs
Protein, Uncoupling
UCPs, Mitochondrial
Uncoupling Protein
Uncoupling Proteins
Uncoupling Proteins, Mitochondrial
Tree number(s): D12.776.157.530.937.598
D12.776.543.585.475.688
D12.776.543.585.937.696
D12.776.575.750.688
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071245
Scope note: Mitochondrial anion carrier proteins that function as dimers and form proton channels in the INNER MITOCHONDRIAL MEMBRANE which creates proton leaks and uncouples OXIDATIVE PHOSPHORYLATION from ATP synthesis, resulting in the generation of heat instead of ATP.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Membrane Proteins (1998-2016)
Mitochondrial Proteins (1998-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56587
Unique ID: D000071245
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2020/05/27
Mitochondrial Uncoupling Proteins - Preferred
Concept UI M000613846
Scope note Mitochondrial anion carrier proteins that function as dimers and form proton channels in the INNER MITOCHONDRIAL MEMBRANE which creates proton leaks and uncouples OXIDATIVE PHOSPHORYLATION from ATP synthesis, resulting in the generation of heat instead of ATP.
Preferred term Mitochondrial Uncoupling Proteins
Entry term(s) Mitochondrial UCPs
Protein, Uncoupling
UCPs, Mitochondrial
Uncoupling Protein
Uncoupling Proteins
Uncoupling Proteins, Mitochondrial



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