Search
Descriptor English: Mitochondrial Permeability Transition Pore
Descriptor Spanish: Poro de Transición de la Permeabilidad Mitocondrial
Descriptor Portuguese: Poro de Transição de Permeabilidade Mitocondrial
Descriptor French: Without translation
Entry term(s): Mitochondrial Megachannel
Mitochondrial Permeability Transition Pore (mPTP)
mPTP Protein
Tree number(s): D05.500.437
D12.776.543.585.475.563
D12.776.575.750.563
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000083162
Scope note: A multiprotein inner mitochondrial complex which opens only under certain pathological conditions (e.g., OXIDATIVE STRESS) uncoupling the membrane leading to APOPTOSIS and MITOCHONDRIAL TRANSMEMBRANE PERMEABILITY-DRIVEN NECROSIS particularly in CARDIOMYOCYTES during MYOCARDIAL REPERFUSION INJURY.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Public MeSH Note: Mitochondrial Permeability Transition Pore was indexed under MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS 2007-2020; ION CHANNELS 2003-2006; MEMBRANE PROTEINS 1999-2002; CYCLOSPORINS 1999-2000
History Note: 2021(1999)
DeCS ID: 59372
Unique ID: D000083162
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2021/01/01
Date of Entry: 2020/07/07
Revision Date: 2020/02/21
Mitochondrial Permeability Transition Pore - Preferred
Concept UI M000678777
Scope note A multiprotein inner mitochondrial complex which opens only under certain pathological conditions (e.g., OXIDATIVE STRESS) uncoupling the membrane leading to APOPTOSIS and MITOCHONDRIAL TRANSMEMBRANE PERMEABILITY-DRIVEN NECROSIS particularly in CARDIOMYOCYTES during MYOCARDIAL REPERFUSION INJURY.
Preferred term Mitochondrial Permeability Transition Pore
Entry term(s) Mitochondrial Megachannel
Mitochondrial Permeability Transition Pore (mPTP)
mPTP Protein



We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.


Go to survey