| Descriptor English: | Mitochondrial Permeability Transition Pore | ||||||
| Descriptor Spanish: |
Poro de Transición de la Permeabilidad Mitocondrial
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| Descriptor Portuguese: | Poro de Transição de Permeabilidade Mitocondrial | ||||||
| Descriptor French: | Pore de transition de perméabilité mitochondriale | ||||||
| Entry term(s): |
Mitochondrial Megachannel Mitochondrial Permeability Transition Pore (mPTP) mPTP Protein |
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| Tree number(s): |
D05.500.437 D12.776.543.585.475.563 D12.776.575.750.563 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000083162 | ||||||
| Scope note: | A multiprotein inner mitochondrial complex which opens only under certain pathological conditions (e.g., OXIDATIVE STRESS) uncoupling the membrane leading to APOPTOSIS and MITOCHONDRIAL TRANSMEMBRANE PERMEABILITY-DRIVEN NECROSIS particularly in CARDIOMYOCYTES during MYOCARDIAL REPERFUSION INJURY. |
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| Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
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| Public MeSH Note: | Mitochondrial Permeability Transition Pore was indexed under MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS 2007-2020; ION CHANNELS 2003-2006; MEMBRANE PROTEINS 1999-2002; CYCLOSPORINS 1999-2000 |
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| History Note: | 2021(1999) |
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| DeCS ID: | 59372 | ||||||
| Unique ID: | D000083162 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2021/01/01 | ||||||
| Date of Entry: | 2020/07/07 | ||||||
| Revision Date: | 2020/02/21 |
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CHEMICALS AND DRUGS
Macromolecular Substances [D05]Macromolecular Substances -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Mitochondrial Permeability Transition Pore
- Preferred
| Concept UI |
M000678777 |
| Scope note | A multiprotein inner mitochondrial complex which opens only under certain pathological conditions (e.g., OXIDATIVE STRESS) uncoupling the membrane leading to APOPTOSIS and MITOCHONDRIAL TRANSMEMBRANE PERMEABILITY-DRIVEN NECROSIS particularly in CARDIOMYOCYTES during MYOCARDIAL REPERFUSION INJURY. |
| Preferred term | Mitochondrial Permeability Transition Pore |
| Entry term(s) |
Mitochondrial Megachannel Mitochondrial Permeability Transition Pore (mPTP) mPTP Protein |
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