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Descriptor English: Exenatide
Descriptor Spanish: Exenatida
Descriptor exenatida
Entry term(s) AC 2993
AC 2993 LAR
ITCA 650
bydureon
byetta
exendina 4
exendina-4
péptido Ex4
Scope note: Forma sintética de la exendina-4, un péptido de 39 aminoácidos aislado del veneno del lagarto MONSTRUO DE GILA (Heloderma suspectum). La exenatida aumenta los niveles de AMP CÍCLICO en las células de los acinos pancreáticos y actúa como agonista del RECEPTOR DEL PÉPTIDO 1 SIMILAR AL GLUCAGÓN (GLP-1) y mimético de las incretinas, estimulando la secreción de insulina en respuesta al aumento de los niveles de glucosa; también suprime la secreción inadecuada de glucagón y ralentiza el vaciado gástrico. Se usa como fármaco antidiabético y antiobesidad.
Descriptor Portuguese: Exenatida
Descriptor French: Exénatide
Entry term(s): AC 2993
AC 2993 LAR
Bydureon
Byetta
Ex4 Peptide
Exendin 4
Exendin-4
ITCA 650
Peptide, Ex4
Tree number(s): D12.644.187
D20.888.300
D23.946.833.300
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077270
Scope note: A synthetic form of exendin-4, a 39-amino acid peptide isolated from the venom of the GILA MONSTER lizard (Heloderma suspectum). Exenatide increases CYCLIC AMP levels in pancreatic acinar cells and acts as a GLUCAGON-LIKE PEPTIDE-1 RECEPTOR (GLP-1) agonist and incretin mimetic, enhancing insulin secretion in response to increased glucose levels; it also suppresses inappropriate glucagon secretion and slows gastric emptying. It is used as an anti-diabetic and anti-obesity agent.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Hypoglycemic Agents
Anti-Obesity Agents
Incretins
Registry Number: 9P1872D4OL
Public MeSH Note: 2019; EXENATIDE was indexed under PEPTIDES and VENOMS 1992-2018
History Note: 2019 (1992)
DeCS ID: 57573
Unique ID: D000077270
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/06/19
Exenatide - Preferred
Concept UI M0199975
Scope note A synthetic form of exendin-4, a 39-amino acid peptide isolated from the venom of the GILA MONSTER lizard (Heloderma suspectum). Exenatide increases CYCLIC AMP levels in pancreatic acinar cells and acts as a GLUCAGON-LIKE PEPTIDE-1 RECEPTOR (GLP-1) agonist and incretin mimetic, enhancing insulin secretion in response to increased glucose levels; it also suppresses inappropriate glucagon secretion and slows gastric emptying. It is used as an anti-diabetic and anti-obesity agent.
Preferred term Exenatide
Bydureon - Narrower
Concept UI M0578345
Preferred term Bydureon
ITCA 650 - Narrower
Concept UI M0590014
Preferred term ITCA 650
AC 2993 LAR - Narrower
Concept UI M0445897
Preferred term AC 2993 LAR
Exendin-4 - Broader
Concept UI M000640237
Preferred term Exendin-4
Entry term(s) Ex4 Peptide
Exendin 4
Peptide, Ex4
Byetta - Narrower
Concept UI M0502852
Preferred term Byetta
AC 2993 - Narrower
Concept UI M0445896
Preferred term AC 2993



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