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Descriptor in English: Heme Oxygenase (Decyclizing)
Descriptor in Spanish: Hemo Oxigenasa (Desciclizante)
Descriptor in Portuguese: Heme Oxigenase (Desciclizante)
Descriptor in French: Heme oxygenase (decyclizing)
Entry term(s): Haem Oxygenase
Heme Oxygenase
Oxygenase, Haem
Oxygenase, Heme
Tree number(s): D08.811.682.690.708.410
Scope note: A mixed function oxidase enzyme which during hemoglobin catabolism catalyzes the degradation of heme to ferrous iron, carbon monoxide and biliverdin in the presence of molecular oxygen and reduced NADPH. The enzyme is induced by metals, particularly cobalt.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
History Note: 98; was HEME OXYGENASE 1980-97 (see under HYDROXYLASES 1980-90)
DeCS UI: 6568
Descriptor UI: D006419
Date Established: 1991/01/01
Date of Entry: 1979/02/21
Revision Date: 2016/06/01
Heme Oxygenase (Decyclizing) - Preferred
Concept UI M0010067
Scope note A mixed function oxidase enzyme which during hemoglobin catabolism catalyzes the degradation of heme to ferrous iron, carbon monoxide and biliverdin in the presence of molecular oxygen and reduced NADPH. The enzyme is induced by metals, particularly cobalt.
Preferred term Heme Oxygenase (Decyclizing)
Entry term(s) Haem Oxygenase
Heme Oxygenase
Oxygenase, Haem
Oxygenase, Heme



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