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Descriptor English: Heme Oxygenase (Decyclizing)
Descriptor Spanish: Hemo Oxigenasa (Desciclizante)
Descriptor hemo oxigenasa (desciclizante)
Entry term(s) hemo oxigenasa
Scope note: Enzima oxidasa de función mixta que, durante el catabolismo de la hemoglobina, cataliza la degradación del hemo a hierro ferroso, monóxido de carbono y biliverdina, en presencia de oxígeno molecular y NADPH reducido. La enzima es inducida por metales, particularmente el cobalto.
Descriptor Portuguese: Heme Oxigenase (Desciclizante)
Descriptor French: Heme oxygenase (decyclizing)
Entry term(s): Haem Oxygenase
Heme Oxygenase
Oxygenase, Haem
Oxygenase, Heme
Tree number(s): D08.811.682.690.708.410
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D006419
Scope note: A mixed function oxidase enzyme which during hemoglobin catabolism catalyzes the degradation of heme to ferrous iron, carbon monoxide and biliverdin in the presence of molecular oxygen and reduced NADPH. The enzyme is induced by metals, particularly cobalt.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 1.14.14.18
CAS Type 1 Name: Heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)
Previous Indexing: Heme (1966-1979)
Hydroxylases (1966-1979)
Oxygenases (1966-1979)
Public MeSH Note: 98; was HEME OXYGENASE 1980-97 (see under HYDROXYLASES 1980-90)
History Note: 98; was HEME OXYGENASE 1980-97 (see under HYDROXYLASES 1980-90)
DeCS ID: 6568
Unique ID: D006419
NLM Classification: QU 140
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1979/02/21
Revision Date: 2016/06/01
Heme Oxygenase (Decyclizing) - Preferred
Concept UI M0010067
Scope note A mixed function oxidase enzyme which during hemoglobin catabolism catalyzes the degradation of heme to ferrous iron, carbon monoxide and biliverdin in the presence of molecular oxygen and reduced NADPH. The enzyme is induced by metals, particularly cobalt.
Preferred term Heme Oxygenase (Decyclizing)
Entry term(s) Haem Oxygenase
Heme Oxygenase
Oxygenase, Haem
Oxygenase, Heme



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