Search
Descriptor in English: Cytochrome P-450 Enzyme System
Descriptor in Spanish: Sistema Enzimático del Citocromo P-450
Descriptor in Portuguese: Sistema Enzimático do Citocromo P-450
Descriptor in French: Cytochrome P-450 enzyme system
Entry term(s): CYP450 Family
CYP450 Superfamily
Cytochrome P 450
Cytochrome P 450 Dependent Monooxygenase
Cytochrome P 450 Enzyme System
Cytochrome P 450 Enzymes
Cytochrome P 450 Families
Cytochrome P 450 Monooxygenase
Cytochrome P 450 Oxygenase
Cytochrome P 450 Superfamily
Cytochrome P-450
Cytochrome P-450 Enzymes
Cytochrome P-450 Families
Cytochrome P-450 Monooxygenase
Cytochrome P-450 Oxygenase
Cytochrome P-450 Superfamily
Cytochrome P-450-Dependent Monooxygenase
Cytochrome P450
Cytochrome P450 Superfamily
Cytochrome p450 Families
Enzymes, Cytochrome P-450
Enzymes, P-450
Enzymes, P450
Monooxygenase, Cytochrome P-450
Monooxygenase, Cytochrome P-450-Dependent
P 450 Enzymes
P-450 Enzymes
P-450 Enzymes, Cytochrome
P450 Enzymes
Superfamily, CYP450
Superfamily, Cytochrome P-450
Superfamily, Cytochrome P450
Tree number(s): D08.244.453
D08.811.682.690.708.170
D12.776.422.220.453
Scope note: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Annotation: general or unspecified; prefer specific cytochrome P-450's
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
History Note: 73; CYTOCHROME P-450 OXYGENASE was NM 1977-96
DeCS UI: 3595
Descriptor UI: D003577
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/27
Cytochrome P-450 Enzyme System - Preferred
Concept UI M0005591
Scope note A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Preferred term Cytochrome P-450 Enzyme System
Entry term(s) CYP450 Family
CYP450 Superfamily
Cytochrome P 450
Cytochrome P 450 Enzyme System
Cytochrome P 450 Enzymes
Cytochrome P 450 Families
Cytochrome P 450 Superfamily
Cytochrome P-450
Cytochrome P-450 Enzymes
Cytochrome P-450 Families
Cytochrome P-450 Superfamily
Cytochrome P450
Cytochrome P450 Superfamily
Cytochrome p450 Families
Enzymes, Cytochrome P-450
Enzymes, P-450
Enzymes, P450
P 450 Enzymes
P-450 Enzymes
P-450 Enzymes, Cytochrome
P450 Enzymes
Superfamily, CYP450
Superfamily, Cytochrome P-450
Superfamily, Cytochrome P450
Cytochrome P-450 Monooxygenase - Narrower
Concept UI M0005593
Preferred term Cytochrome P-450 Monooxygenase
Entry term(s) Cytochrome P 450 Dependent Monooxygenase
Cytochrome P 450 Monooxygenase
Cytochrome P-450-Dependent Monooxygenase
Monooxygenase, Cytochrome P-450
Monooxygenase, Cytochrome P-450-Dependent
Cytochrome P-450 Oxygenase - Narrower
Concept UI M0005592
Preferred term Cytochrome P-450 Oxygenase
Entry term(s) Cytochrome P 450 Oxygenase



We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.


Go to survey