| Descriptor English: | Cytochrome P-450 Enzyme System | ||||||
| Descriptor Spanish: |
Sistema Enzimático del Citocromo P-450
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| Descriptor Portuguese: | Sistema Enzimático do Citocromo P-450 | ||||||
| Descriptor French: | Cytochrome P-450 enzyme system | ||||||
| Entry term(s): |
CYP450 Family CYP450 Superfamily Cytochrome P 450 Cytochrome P 450 Dependent Monooxygenase Cytochrome P 450 Enzyme Cytochrome P 450 Enzyme System Cytochrome P 450 Enzymes Cytochrome P 450 Families Cytochrome P 450 Monooxygenase Cytochrome P 450 Oxygenase Cytochrome P 450 Superfamily Cytochrome P-450 Cytochrome P-450 Enzyme Cytochrome P-450 Enzymes Cytochrome P-450 Families Cytochrome P-450 Monooxygenase Cytochrome P-450 Oxygenase Cytochrome P-450 Superfamily Cytochrome P-450-Dependent Monooxygenase Cytochrome P450 Cytochrome P450 Superfamily Cytochrome p450 Families Enzyme, Cytochrome P-450 Enzyme, P-450 Enzyme, P450 Enzymes, Cytochrome P-450 Enzymes, P-450 Enzymes, P450 Monooxygenase, Cytochrome P-450 Monooxygenase, Cytochrome P-450-Dependent P 450 Enzyme P 450 Enzymes P-450 Enzyme P-450 Enzyme, Cytochrome P-450 Enzymes P-450 Enzymes, Cytochrome P450 Enzyme P450 Enzymes Superfamily, CYP450 Superfamily, Cytochrome P-450 Superfamily, Cytochrome P450 |
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| Tree number(s): |
D08.244.453 D08.811.682.690.708.170 D12.776.422.220.453 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D003577 | ||||||
| Scope note: | A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism. |
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| Annotation: | general or unspecified; prefer specific cytochrome P-450's |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Entry Combination: |
antagonists & inhibitors:Cytochrome P-450 Enzyme Inhibitors
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| Registry Number: | 9035-51-2 | ||||||
| CAS Type 1 Name: | Cytochrome P 450 | ||||||
| Previous Indexing: |
Cytochromes (1966-1972) |
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| Public MeSH Note: | 73; CYTOCHROME P-450 OXYGENASE was indexed under CYTOCHROME P-450 & OXYGENASES 1977-96 |
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| History Note: | 73; CYTOCHROME P-450 OXYGENASE was NM 1977-96 |
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| DeCS ID: | 3595 | ||||||
| Unique ID: | D003577 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1973/01/01 | ||||||
| Date of Entry: | 1999/01/01 | ||||||
| Revision Date: | 2020/05/27 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Cytochrome P-450 Enzyme System
- Preferred
Cytochrome P-450 Monooxygenase
- Narrower
Cytochrome P-450 Oxygenase
- Narrower
| Concept UI |
M0005591 |
| Scope note | A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism. |
| Preferred term | Cytochrome P-450 Enzyme System |
| Entry term(s) |
CYP450 Family CYP450 Superfamily Cytochrome P 450 Cytochrome P 450 Enzyme Cytochrome P 450 Enzyme System Cytochrome P 450 Enzymes Cytochrome P 450 Families Cytochrome P 450 Superfamily Cytochrome P-450 Cytochrome P-450 Enzyme Cytochrome P-450 Enzymes Cytochrome P-450 Families Cytochrome P-450 Superfamily Cytochrome P450 Cytochrome P450 Superfamily Cytochrome p450 Families Enzyme, Cytochrome P-450 Enzyme, P-450 Enzyme, P450 Enzymes, Cytochrome P-450 Enzymes, P-450 Enzymes, P450 P 450 Enzyme P 450 Enzymes P-450 Enzyme P-450 Enzyme, Cytochrome P-450 Enzymes P-450 Enzymes, Cytochrome P450 Enzyme P450 Enzymes Superfamily, CYP450 Superfamily, Cytochrome P-450 Superfamily, Cytochrome P450 |
| Concept UI |
M0005593 |
| Preferred term | Cytochrome P-450 Monooxygenase |
| Entry term(s) |
Cytochrome P 450 Dependent Monooxygenase Cytochrome P 450 Monooxygenase Cytochrome P-450-Dependent Monooxygenase Monooxygenase, Cytochrome P-450 Monooxygenase, Cytochrome P-450-Dependent |
| Concept UI |
M0005592 |
| Preferred term | Cytochrome P-450 Oxygenase |
| Entry term(s) |
Cytochrome P 450 Oxygenase |
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