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Descriptor English: Molindone
Descriptor Spanish: Molindona
Descriptor molindona
Scope note: Derivado indólico eficaz en la esquizofrenia y otras psicosis y, posiblemente, útil en el tratamiento del tipo agresivo de trastornos de la conducta sub-sociales. La molindona tiene mucha menos afinidad para los receptores D2 que la mayoría de los agentes antipsicóticos y tiene relativamente baja afinidad para los receptores D1. Su afinidad por los receptores colinérgicos y alfa-adrenérgicos es baja o moderada. Algunos datos electrofisiológicos de animales indican que la molindona tiene ciertas características que la asemejan a la CLOZAPINA. (de AMA Drug Evaluations Annual, 1994, p283)
Descriptor Portuguese: Molindona
Descriptor French: Molindone
Entry term(s): Hydrochloride, Molindone
Moban
Molindone Hydrochloride
Molindone Monohydrochloride
Monohydrochloride, Molindone
Tree number(s): D03.633.100.473.629
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D008972
Scope note: An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of CLOZAPINE. (From AMA Drug Evaluations Annual, 1994, p283)
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antipsychotic Agents
Registry Number: RT3Y3QMF8N
CAS Type 1 Name: 4H-Indol-4-one, 3-ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-
Previous Indexing: Antidepressive Agents (1966-1971)
Indoles (1966-1971)
Public MeSH Note: 91; was see under INDOLES 1972-90
History Note: 91(72); was see under INDOLES 1972-90
DeCS ID: 9160
Unique ID: D008972
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1999/01/01
Revision Date: 2017/05/24
Molindone - Preferred
Concept UI M0013989
Scope note An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of CLOZAPINE. (From AMA Drug Evaluations Annual, 1994, p283)
Preferred term Molindone
Moban - Narrower
Concept UI M0013990
Preferred term Moban
Molindone Hydrochloride - Narrower
Concept UI M0330042
Preferred term Molindone Hydrochloride
Entry term(s) Hydrochloride, Molindone
Molindone Monohydrochloride
Monohydrochloride, Molindone



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