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Descriptor English: Pyrantel
Descriptor Spanish: Pirantel
Descriptor pirantel
Scope note: Agente bloqueante neuromuscular despolarizante, que produce activación nicotínica persistente que determina una parálisis espástica de los nemátodos susceptibles. Es un fármaco de segunda elección, después de los benzimidazoles, para el tratamiento de la ascariasis, infecciones por anquilostoma y oxiuro, con eficacia tras una dosis única.
Descriptor Portuguese: Pirantel
Descriptor French: Pyrantel
Tree number(s): D02.886.778.634
D03.383.742.634
D03.383.903.634
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011715
Scope note: A depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes. It is a drug of second-choice after benzimidazoles for treatment of ascariasis, hookworm, and pinworm infections, being effective after a single dose. (From Smith and Reynard, Textbook of Pharmacology, 1992, p920)
Annotation: an antinematodal agent
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antinematodal Agents
Neuromuscular Depolarizing Agents
Registry Number: 4QIH0N49E7
CAS Type 1 Name: Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)ethenyl)-, (E)-
Public MeSH Note: 74
History Note: 74
DeCS ID: 12151
Unique ID: D011715
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/31
Pyrantel - Preferred
Concept UI M0018221
Scope note A depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes. It is a drug of second-choice after benzimidazoles for treatment of ascariasis, hookworm, and pinworm infections, being effective after a single dose. (From Smith and Reynard, Textbook of Pharmacology, 1992, p920)
Preferred term Pyrantel



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