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Descriptor in English: Imatinib Mesylate
Descriptor in Spanish: Mesilato de Imatinib
Descriptor in Portuguese: Mesilato de Imatinib
Descriptor in French: Mésilate d'imatinib
Entry term(s): Alpha-(4-methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-tolu-p-toluidide
CGP 57148
CGP-57148
CGP57148
CGP57148B
Gleevec
Glivec
Imatinib
Imatinib Methanesulfonate
Mesylate, Imatinib
Methanesulfonate, Imatinib
ST 1571
ST1571
STI 571
STI-571
STI571
Tree number(s): D02.065.277.456
D02.241.223.100.100.435
D02.455.426.559.389.127.085.465
D03.383.606.405
D03.383.742.349
Scope note: A tyrosine kinase inhibitor and ANTINEOPLASTIC AGENT that inhibits the BCR-ABL kinase created by chromosome rearrangements in CHRONIC MYELOID LEUKEMIA and ACUTE LYMPHOBLASTIC LEUKEMIA, as well as PDG-derived tyrosine kinases that are overexpressed in gastrointestinal stromal tumors.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
History Note: 2016 (1996)
DeCS UI: 55873
Descriptor UI: D000068877
Date Established: 2016/01/01
Date of Entry: 2015/07/09
Revision Date: 2016/05/31
Imatinib Mesylate - Preferred
Concept UI M0391958
Scope note A tyrosine kinase inhibitor and ANTINEOPLASTIC AGENT that inhibits the BCR-ABL kinase created by chromosome rearrangements in CHRONIC MYELOID LEUKEMIA and ACUTE LYMPHOBLASTIC LEUKEMIA, as well as PDG-derived tyrosine kinases that are overexpressed in gastrointestinal stromal tumors.
Preferred term Imatinib Mesylate
Entry term(s) Imatinib Methanesulfonate
Mesylate, Imatinib
Methanesulfonate, Imatinib
STI571 - Narrower
Concept UI M0368581
Preferred term STI571
Entry term(s) STI 571
STI-571
Gleevec - Narrower
Concept UI M0392345
Preferred term Gleevec
Entry term(s) Glivec
ST 1571 - Narrower
Concept UI M0400371
Preferred term ST 1571
Entry term(s) ST1571
CGP 57148 - Narrower
Concept UI M0256578
Preferred term CGP 57148
Entry term(s) CGP-57148
CGP57148
CGP57148B
Imatinib - Broader
Concept UI M0424454
Preferred term Imatinib
Entry term(s) Alpha-(4-methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-tolu-p-toluidide



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