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Descriptor English:

Trimethoprim

Descriptor Spanish:

Trimetoprim

Spanish from Spain

Descriptor	trimetoprim
Scope note:	Inhibidor pirimidina de la dihidrofolato reductasa y antibacteriano relacionado con la PIRIMETAMINA. Su acción es potenciada por las SULFONAMIDAS y la COMBINACIÓN TRIMETOPRIM-SULFAMETOXAZOL es la forma más comúnmente utilizada. En ocasiones se utiliza aisladamente como fármaco antipalúdico. Se han publicado RESISTENCIAS AL TRIMETOPRIM.

Descriptor Portuguese:

Trimetoprima

Descriptor French:

Triméthoprime

Tree number(s):

D03.383.742.906

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D014295

Scope note:

A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.

Annotation:

consider TRIMETHOPRIM RESISTANCE for nonsusceptibility of bacteria

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Anti-Infective Agents, Urinary
Antimalarials
Folic Acid Antagonists
Anti-Dyskinesia Agents
Cytochrome P-450 CYP2C8 Inhibitors

Registry Number:

AN164J8Y0X

CAS Type 1 Name:

2,4-Pyrimidinediamine, 5-((3,4,5-trimethoxyphenyl)methyl)-

Résistance au triméthoprime MeSH

DeCS ID:

14697

Unique ID:

D014295

NLM Classification: