| Descriptor English: | Trimethoprim | ||||
| Descriptor Spanish: |
Trimetoprim
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| Descriptor Portuguese: | Trimetoprima | ||||
| Descriptor French: | Triméthoprime | ||||
| Entry term(s): |
Proloprim Trimpex |
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| Tree number(s): |
D03.383.742.906 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D014295 | ||||
| Scope note: | A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported. |
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| Annotation: | consider TRIMETHOPRIM RESISTANCE for nonsusceptibility of bacteria |
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| Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
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| Pharm Action: |
Anti-Infective Agents, Urinary Antiinfecciosos Urinarios Anti-Infecciosos Urinários Anti-infectieux urinaires antiinfecciosos urinarios Antimalarials Antimaláricos Antimaláricos Antipaludiques antimaláricos Folic Acid Antagonists Antagonistas del Ácido Fólico Antagonistas do Ácido Fólico Antifoliques antagonistas del ácido fólico Anti-Dyskinesia Agents Antidiscinéticos Antidiscinéticos Antidyskinésiques antidiscinéticos Cytochrome P-450 CYP2C8 Inhibitors Inhibidores del Citocromo P-450 CYP2C8 Inibidores do Citocromo P-450 CYP2C8 Inhibiteurs du cytochrome P-450 CYP2C8 inhibidores del citocromo P-450 CYP2C8 |
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| Registry Number: | AN164J8Y0X | ||||
| CAS Type 1 Name: | 2,4-Pyrimidinediamine, 5-((3,4,5-trimethoxyphenyl)methyl)- | ||||
| Previous Indexing: |
Anti-Infective Agents (1966-1971) Folic Acid Antagonists (1966-1971) Pyrimidines (1966-1971) |
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| Public MeSH Note: | 1974 |
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| History Note: | 1974 (1972) |
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| Related: |
Trimethoprim Resistance
MeSH | ||||
| DeCS ID: | 14697 | ||||
| Unique ID: | D014295 | ||||
| NLM Classification: | QV 256 | ||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||
| Date Established: | 1974/01/01 | ||||
| Date of Entry: | 1999/01/01 | ||||
| Revision Date: | 2018/05/21 |
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CHEMICALS AND DRUGS
Heterocyclic Compounds [D03]Heterocyclic Compounds
|
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Trimethoprim
- Preferred
Trimpex
- Narrower
Proloprim
- Narrower
| Concept UI |
M0021991 |
| Scope note | A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported. |
| Preferred term | Trimethoprim |
| Concept UI |
M0373256 |
| Preferred term | Trimpex |
| Concept UI |
M0373257 |
| Preferred term | Proloprim |
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