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Descriptor English: Trimethoprim
Descriptor Spanish: Trimetoprim
Descriptor Portuguese: Trimetoprima
Descriptor French: Triméthoprime
Entry term(s): Proloprim
Trimpex
Tree number(s): D03.383.742.906
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D014295
Scope note: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
Annotation: consider TRIMETHOPRIM RESISTANCE for nonsusceptibility of bacteria
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Infective Agents, Urinary
Antimalarials
Folic Acid Antagonists
Anti-Dyskinesia Agents
Cytochrome P-450 CYP2C8 Inhibitors
Registry Number: AN164J8Y0X
CAS Type 1 Name: 2,4-Pyrimidinediamine, 5-((3,4,5-trimethoxyphenyl)methyl)-
Previous Indexing: Anti-Infective Agents (1966-1971)
Folic Acid Antagonists (1966-1971)
Pyrimidines (1966-1971)
Public MeSH Note: 1974
History Note: 1974 (1972)
Related: Trimethoprim Resistance MeSH
DeCS ID: 14697
Unique ID: D014295
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2018/05/21
Trimethoprim - Preferred
Concept UI M0021991
Scope note A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
Preferred term Trimethoprim
Trimpex - Narrower
Concept UI M0373256
Preferred term Trimpex
Proloprim - Narrower
Concept UI M0373257
Preferred term Proloprim



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