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Descriptor in English: Trimethoprim
Descriptor in Spanish: Trimetoprim
Descriptor in Portuguese: Trimetoprima
Descriptor in French: Triméthoprime
Entry term(s): Proloprim
Trimpex
Tree number(s): D03.383.742.906
Scope note: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
Annotation: consider TRIMETHOPRIM RESISTANCE for nonsusceptibility of bacteria
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
History Note: 1974 (1972)
See also the descriptors: Trimethoprim Resistance MeSH
DeCS UI: 14697
Descriptor UI: D014295
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2018/05/21
Trimethoprim - Preferred
Concept UI M0021991
Scope note A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
Preferred term Trimethoprim
Trimpex - Narrower
Concept UI M0373256
Preferred term Trimpex
Proloprim - Narrower
Concept UI M0373257
Preferred term Proloprim



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