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Descriptor English: Complement C2
Descriptor Spanish: Complemento C2
Descriptor Portuguese: Complemento C2
Descriptor French: Complément C2
Entry term(s): C2 Complement
C2, Complement
Complement 2
Complement Component 2
Complement, C2
Component 2, Complement
Tree number(s): D12.776.124.486.274.150
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003175
Scope note: A component of the CLASSICAL COMPLEMENT PATHWAY. C2 is cleaved by activated COMPLEMENT C1S into COMPLEMENT C2B and COMPLEMENT C2A. C2a, the COOH-terminal fragment containing a SERINE PROTEASE, combines with COMPLEMENT C4B to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE).
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Previous Indexing: Complement (1968-1974)
Magnesium (1966-1974)
Protein Binding (1966-1974)
Public MeSH Note: 2006; see COMPLEMENT 2 1978-2005, see COMPLEMENT 1975-1977
History Note: 2006 (1975)
DeCS ID: 22134
Unique ID: D003175
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1978/01/01
Date of Entry: 1974/11/11
Revision Date: 2005/06/30
Complement C2 - Preferred
Concept UI M0004927
Scope note A component of the CLASSICAL COMPLEMENT PATHWAY. C2 is cleaved by activated COMPLEMENT C1S into COMPLEMENT C2B and COMPLEMENT C2A. C2a, the COOH-terminal fragment containing a SERINE PROTEASE, combines with COMPLEMENT C4B to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE).
Preferred term Complement C2
Entry term(s) C2 Complement
C2, Complement
Complement 2
Complement Component 2
Complement, C2
Component 2, Complement



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