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Descriptor English: Complement C8
Descriptor Spanish: Complemento C8
Descriptor Portuguese: Complemento C8
Descriptor French: Complément C8
Entry term(s): C8 Complement
C8, Complement
Complement 8
Complement Component 8
Complement Component C8 alpha
Complement Component C8 alpha Chain
Complement Component C8 beta
Complement Component C8 beta Chain
Complement Component C8 gamma
Complement Component C8 gamma Chain
Complement, C8
Component 8, Complement
Tree number(s): D12.776.124.486.274.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003185
Scope note: A 150-kDa serum glycoprotein composed of three subunits with each encoded by a different gene (C8A; C8B; and C8G). This heterotrimer contains a disulfide-linked C8alpha-C8gamma heterodimer and a noncovalently associated C8beta chain. C8 is the next component to bind the C5-7 complex forming C5b-8 that binds COMPLEMENT C9 and acts as a catalyst in the polymerization of C9.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Previous Indexing: Bacteriolysis (1966-1974)
Complement (1968-1974)
Hemolysis (1966-1974)
Public MeSH Note: 2006; see COMPLEMENT 8 1978-2005; see COMPLEMENT 1975-1977
History Note: 2006 (1975)
DeCS ID: 22139
Unique ID: D003185
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1978/01/01
Date of Entry: 1974/11/11
Revision Date: 2005/06/30
Complement C8 - Preferred
Concept UI M0004940
Scope note A 150-kDa serum glycoprotein composed of three subunits with each encoded by a different gene (C8A; C8B; and C8G). This heterotrimer contains a disulfide-linked C8alpha-C8gamma heterodimer and a noncovalently associated C8beta chain. C8 is the next component to bind the C5-7 complex forming C5b-8 that binds COMPLEMENT C9 and acts as a catalyst in the polymerization of C9.
Preferred term Complement C8
Entry term(s) C8 Complement
C8, Complement
Complement 8
Complement Component 8
Complement, C8
Component 8, Complement
Complement Component C8 beta - Narrower
Concept UI M0477758
Preferred term Complement Component C8 beta
Entry term(s) Complement Component C8 beta Chain
Complement Component C8 gamma - Narrower
Concept UI M0477759
Preferred term Complement Component C8 gamma
Entry term(s) Complement Component C8 gamma Chain
Complement Component C8 alpha - Narrower
Concept UI M0477757
Preferred term Complement Component C8 alpha
Entry term(s) Complement Component C8 alpha Chain



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