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Descriptor English: Complement C9
Descriptor Spanish: Complemento C9
Descriptor complemento C9
Scope note: Glicoproteína sérica de 63 kDa codificada por el gen C9. C9 monomérico (mC9) se une al complejo C5b-8 para formar C5b-9 que cataliza la polimerización de C9 para formar C5b-p9 (COMPLEJO DE ATAQUE A LA MEMBRANA) y canales transmembranarios que llevan a la lisis de la célula diana. Los pacientes con deficiencia en C9 sufren infecciones bacterianas recurrentes.
Descriptor Portuguese: Complemento C9
Descriptor French: Complément C9
Entry term(s): C9 Complement
C9, Complement
Complement 9
Complement Component 9
Complement, C9
Component 9, Complement
Tree number(s): D12.776.124.486.274.850
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003186
Scope note: A 63-kDa serum glycoprotein encoded by gene C9. Monomeric C9 (mC9) binds the C5b-8 complex to form C5b-9 which catalyzes the polymerization of C9 forming C5b-p9 (MEMBRANE ATTACK COMPLEX) and transmembrane channels leading to lysis of the target cell. Patients with C9 deficiency suffer from recurrent bacterial infections.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Previous Indexing: Bacteriolysis (1966-1974)
Complement (1968-1974)
Hemolysis (1966-1974)
specific cell
Public MeSH Note: 2006; see COMPLEMENT 9 1978-2005, see COMPLEMENT 1975-1977
History Note: 2006 (1975)
DeCS ID: 22140
Unique ID: D003186
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1978/01/01
Date of Entry: 1974/11/11
Revision Date: 2005/06/30
Complement C9 - Preferred
Concept UI M0004941
Scope note A 63-kDa serum glycoprotein encoded by gene C9. Monomeric C9 (mC9) binds the C5b-8 complex to form C5b-9 which catalyzes the polymerization of C9 forming C5b-p9 (MEMBRANE ATTACK COMPLEX) and transmembrane channels leading to lysis of the target cell. Patients with C9 deficiency suffer from recurrent bacterial infections.
Preferred term Complement C9
Entry term(s) C9 Complement
C9, Complement
Complement 9
Complement Component 9
Complement, C9
Component 9, Complement



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