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Descriptor English: Flunarizine
Descriptor Spanish: Flunarizina
Descriptor Portuguese: Flunarizina
Descriptor French: Flunarizine
Entry term(s): Dihydrochloride, Flunarizine
Flunarizin
Flunarizine Dihydrochloride
Flunarizine Hydrochloride
Hydrochloride, Flunarizine
R 14950
R-14950
R14950
Sibelium
Tree number(s): D03.383.606.450
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D005444
Scope note: Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Annotation:
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anticonvulsants
Calcium Channel Blockers
Histamine H1 Antagonists
Vasodilator Agents
Registry Number: R7PLA2DM0J
CAS Type 1 Name: Piperazine, 1-(bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)-, (E)-
Previous Indexing: Cinnarizine/analogs & derivatives (1975-1986)
Piperazines (1966-1974)
Public MeSH Note: 87
History Note: 87
DeCS ID: 23266
Unique ID: D005444
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1987/01/01
Date of Entry: 1986/06/16
Revision Date: 2016/05/31
Flunarizine - Preferred
Concept UI M0008587
Scope note Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Preferred term Flunarizine
Entry term(s) Flunarizin
Sibelium - Narrower
Concept UI M0008588
Preferred term Sibelium
Flunarizine Hydrochloride - Narrower
Concept UI M0330270
Preferred term Flunarizine Hydrochloride
Entry term(s) Dihydrochloride, Flunarizine
Flunarizine Dihydrochloride
Hydrochloride, Flunarizine
R-14950 - Narrower
Concept UI M0008589
Preferred term R-14950
Entry term(s) R 14950
R14950



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