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Descriptor English: Itraconazole
Descriptor Spanish: Itraconazol
Descriptor itraconazol
Scope note: Uno de los AGENTES ANTIFÚNGICOS triiazólicos, que inhibe las enzimas dependientes del citocromo P-450, dificultando la síntesis de ERGOSTEROL. Se ha utilizado en el tratamiento de la histoplasmosis, la blastomicosis, la meningitis criptocócica y la aspergilosis.
Descriptor Portuguese: Itraconazol
Descriptor French: Itraconazole
Entry term(s): Orungal
R 51211
R-51211
R51211
Sporanox
Tree number(s): D03.383.129.799.550
D03.383.606.530
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D017964
Scope note: A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antifungal Agents
14-alpha Demethylase Inhibitors
Cytochrome P-450 CYP3A Inhibitors
Registry Number: 304NUG5GF4
CAS Type 1 Name: 3H-1,2,4-Triazol-3-one, 4-(4-(4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihydro-2-(1-methylpropyl)-
Previous Indexing: Ketoconazole/analogs & derivatives (1984-1993)
Public MeSH Note: 94; ITRACONAZOLE was indexed under KETOCONAZOLE/*analogs & derivatives 1984-93
Online Note: use ITRACONAZOLE (NM) to search ITRACONAZOLE 1984-93
History Note: 94; was ITRACONAZOLE (NM) 1984-93
DeCS ID: 31378
Unique ID: D017964
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1994/01/01
Date of Entry: 1993/06/04
Revision Date: 2017/05/24
Itraconazole - Preferred
Concept UI M0027131
Scope note A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
Preferred term Itraconazole
R-51211 - Narrower
Concept UI M0353161
Preferred term R-51211
Entry term(s) R 51211
R51211
Sporanox - Narrower
Concept UI M0027132
Preferred term Sporanox
Orungal - Narrower
Concept UI M0514453
Preferred term Orungal



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