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Descriptor in English: Aripiprazole
Descriptor in Spanish: Aripiprazol
Descriptor in Portuguese: Aripiprazol
Descriptor in French: Aripiprazole
Entry term(s): 7-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone
Abilify
Aripiprazol
OPC 14597
OPC-14597
Tree number(s): D03.383.606.170
D03.633.100.810.835.122
Scope note: A piperazine and quinolone derivative that is used primarily as an antipsychotic agent. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a post-synaptic antagonist, and an antagonist of SEROTONIN RECEPTOR, 5-HT2A. It is used for the treatment of SCHIZOPHRENIA and BIPOLAR DISORDER, and as an adjunct therapy for the treatment of depression.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
History Note: 2016 (1995)
DeCS UI: 55922
Descriptor UI: D000068180
Date Established: 2016/01/01
Date of Entry: 2015/07/01
Revision Date: 2018/06/20
Aripiprazole - Preferred
Concept UI M000602020
Scope note A piperazine and quinolone derivative that is used primarily as an antipsychotic agent. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a post-synaptic antagonist, and an antagonist of SEROTONIN RECEPTOR, 5-HT2A. It is used for the treatment of SCHIZOPHRENIA and BIPOLAR DISORDER, and as an adjunct therapy for the treatment of depression.
Preferred term Aripiprazole
Entry term(s) 7-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone
Aripiprazol
Abilify - Narrower
Concept UI M000602022
Preferred term Abilify
OPC 14597 - Narrower
Concept UI M0249360
Preferred term OPC 14597
Entry term(s) OPC-14597



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