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Descriptor English: Complement Membrane Attack Complex
Descriptor Spanish: Complejo de Ataque a Membrana del Sistema Complemento
Descriptor complejo de ataque a la membrana del complemento
Entry term(s) complejo C5b-9 del complemento
complejo de ataque a la membrana
Scope note: Producto de la cascada de ACTIVACIÓN DEL COMPLEMENTO, con independencia de las vías, que forma canales transmembranarios que causan la desestructuración de la MEMBRANA CELULAR diana y lisis celular. Se forma por el ensamblaje secuencial de los componentes terminales del complemento (COMPLEMENTO C5B, COMPLEMENTO C6, COMPLEMENTO C7, COMPLEMENTO C8 y COMPLEMENTO C9) en la membrana diana. El C5b-8-poli-C9 resultante es el "complejo de ataque a la membrana" o MAC.
Descriptor Portuguese: Complexo de Ataque à Membrana do Sistema Complemento
Descriptor French: Complexe d'attaque membranaire du complément
Entry term(s): C 5b-9
C5b 8 poly C9
C5b-8-poly-C9
C5b-9
Complement Complex C5b 9
Complement Complex C5b-9
Complement Complex, Terminal
Complex, Terminal Complement
Cytolytic Terminal Complement Complex
Membrane Attack Complex
Terminal Complement Complex
Tree number(s): D12.776.124.486.274.930
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015938
Scope note: A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Previous Indexing: Complement (1973-1989)
Public MeSH Note: 90
History Note: 90
Entry Version: COMPLEMENT MAC
DeCS ID: 24583
Unique ID: D015938
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 2005/06/30
Complement Membrane Attack Complex - Preferred
Concept UI M0024383
Scope note A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC.
Preferred term Complement Membrane Attack Complex
Entry term(s) C 5b-9
C5b 8 poly C9
C5b-8-poly-C9
C5b-9
Complement Complex C5b 9
Complement Complex C5b-9
Complement Complex, Terminal
Complex, Terminal Complement
Cytolytic Terminal Complement Complex
Membrane Attack Complex
Terminal Complement Complex



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