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Descriptor English: Integrins
Descriptor Spanish: Integrinas
Descriptor integrinas
Entry term(s) integridad
Scope note: Familia de glicoproteínas transmembrana (GLICOPROTEÍNAS DE MEMBRANA), constituidas por heterodímeros no covalentes. Interactúan con una gran variedad de ligandos, incluidas las PROTEÍNAS DE MATRIZ EXTRACELULAR, el COMPLEMENTO y otras células, mientras que sus dominios intracelulares interactúan con el CITOESQUELETO. Se han identificado al menos tres familias de integrinas: los RECEPTORES DE CITOADHESINA, los RECEPTORES DE ADHESIÓN DE LEUCOCITO y los RECEPTORES DE ANTÍGENO MUY TARDÍO. Cada familia tiene una subunidad beta común (CADENAS BETA DE INTEGRINAS) combinada con una o más subunidades alfa diferentes (CADENAS ALFA DE INTEGRINAS). Estos receptores participan en la adhesión célula-matriz y célula-célula en muchos procesos fisiológicos importantes, como el desarrollo embrionario, la HEMOSTASIA, la TROMBOSIS, la CICATRIZACIÓN DE HERIDAS, los mecanismos de defensa inmune y no inmune y la transformación oncogénica.
Descriptor Portuguese: Integrinas
Descriptor French: Intégrines
Entry term(s): Integrin
Tree number(s): D12.776.543.750.705.408
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016023
Scope note: A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
Annotation: prefer specifics
Allowable Qualifiers: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Previous Indexing: Glycoproteins (1966-1987)
Membrane Glycoproteins (1988-1989)
Receptors, Endogenous Substances (1973-1989)
Receptors, Immunologic (1980-1989)
Public MeSH Note: 90
History Note: 90
Related: Cell Adhesion Molecules MeSH
DeCS ID: 24746
Unique ID: D016023
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/07/07
Revision Date: 2020/05/27
Integrins - Preferred
Concept UI M0024497
Scope note A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
Preferred term Integrins
Entry term(s) Integrin



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