PHENOMENA AND PROCESSES Chemical Phenomena [G02] Chemical Phenomena Biochemical Phenomena [G02.111] Biochemical Phenomena Acid-Base Equilibrium [G02.111.007] Acid-Base Equilibrium Acylation [G02.111.012] Acylation Aerobiosis [G02.111.017] Aerobiosis Agglutination [G02.111.026] Agglutination Alkylation [G02.111.035] Alkylation Allosteric Regulation [G02.111.044] Allosteric Regulation Amination [G02.111.053] Amination Anaerobiosis [G02.111.062] Anaerobiosis Autotrophic Processes [G02.111.071] Autotrophic Processes Base Composition [G02.111.080] Base Composition Binding, Competitive [G02.111.084] Binding, Competitive Biocatalysis [G02.111.086] Biocatalysis Biomineralization [G02.111.092] Biomineralization Biosynthetic Pathways [G02.111.098] Biosynthetic Pathways Biotinylation [G02.111.109] Biotinylation Body Composition [G02.111.130] Body Composition Brain Chemistry [G02.111.150] Brain Chemistry Carbohydrate Metabolism [G02.111.158] Carbohydrate Metabolism Citric Acid Cycle [G02.111.165] Citric Acid Cycle Cyclization [G02.111.180] Cyclization Dealkylation [G02.111.188] Dealkylation Deamination [G02.111.192] Deamination Decarboxylation [G02.111.195] Decarboxylation DNA Cleavage [G02.111.210] DNA Cleavage DNA Methylation [G02.111.218] DNA Methylation DNA Repair [G02.111.222] DNA Repair DNA Replication [G02.111.225] DNA Replication Down-Regulation [G02.111.240] Down-Regulation Electron Transport [G02.111.248] Electron Transport Energy Transfer [G02.111.255] Energy Transfer Enzyme Activation [G02.111.263] Enzyme Activation Esterification [G02.111.270] Esterification Halogenation [G02.111.323] Halogenation Heterotrophic Processes [G02.111.375] Heterotrophic Processes Hydrogenation [G02.111.380] Hydrogenation Hydroxylation [G02.111.385] Hydroxylation Kinetics [G02.111.490] Kinetics Lipid Peroxidation [G02.111.515] Lipid Peroxidation Lipogenesis [G02.111.528] Lipogenesis Lipolysis [G02.111.534] Lipolysis Lipoylation [G02.111.540] Lipoylation Melanogenesis [G02.111.545] Melanogenesis Membrane Fluidity [G02.111.550] Membrane Fluidity Molecular Mimicry [G02.111.560] Molecular Mimicry Molecular Structure [G02.111.570] Molecular Structure Nitrogen Cycle [G02.111.587] Nitrogen Cycle Nitrosation [G02.111.595] Nitrosation Nucleic Acid Denaturation [G02.111.603] Nucleic Acid Denaturation Nucleic Acid Hybridization [G02.111.611] Nucleic Acid Hybridization Nucleic Acid Renaturation [G02.111.619] Nucleic Acid Renaturation Osmoregulation [G02.111.635] Osmoregulation Osmosis [G02.111.655] Osmosis Peptide Biosynthesis [G02.111.660] Peptide Biosynthesis Phosphorylation [G02.111.665] Phosphorylation Phototrophic Processes [G02.111.669] Phototrophic Processes Prenylation [G02.111.672] Prenylation Protein Aggregation, Pathological [G02.111.675] Protein Aggregation, Pathological Protein Binding [G02.111.679] Protein Binding Protein Folding [G02.111.688] Protein Folding Protein Modification, Translational [G02.111.691] Protein Modification, Translational Protein Multimerization [G02.111.694] Protein Multimerization Protein Stability [G02.111.700] Protein Stability Proteolysis [G02.111.720] Proteolysis Proteostasis [G02.111.730] Proteostasis RNA Cleavage [G02.111.740] RNA Cleavage RNA Folding [G02.111.750] RNA Folding RNA Processing, Post-Transcriptional [G02.111.760] RNA Processing, Post-Transcriptional RNA Replication [G02.111.770] RNA Replication RNA Stability [G02.111.780] RNA Stability Sequence Homology [G02.111.810] Sequence Homology Signal Transduction [G02.111.820] Signal Transduction Structure-Activity Relationship [G02.111.830] Structure-Activity Relationship Substrate Cycling [G02.111.833] Substrate Cycling Substrate Specificity [G02.111.835] Substrate Specificity Transcription, Genetic [G02.111.873] Transcription, Genetic Up-Regulation [G02.111.905] Up-Regulation PHENOMENA AND PROCESSES Genetic Phenomena [G05] Genetic Phenomena Gene Expression Regulation [G05.308] Gene Expression Regulation Catabolite Repression [G05.308.048] Catabolite Repression Chromatin Assembly and Disassembly [G05.308.095] Chromatin Assembly and Disassembly Down-Regulation [G05.308.200] Down-Regulation Ectopic Gene Expression [G05.308.202] Ectopic Gene Expression Epigenesis, Genetic [G05.308.203] Epigenesis, Genetic Epistasis, Genetic [G05.308.207] Epistasis, Genetic Frameshifting, Ribosomal [G05.308.215] Frameshifting, Ribosomal Gene Amplification [G05.308.250] Gene Amplification Gene Expression Regulation, Archaeal [G05.308.290] Gene Expression Regulation, Archaeal Gene Expression Regulation, Bacterial [G05.308.300] Gene Expression Regulation, Bacterial Gene Expression Regulation, Developmental [G05.308.310] Gene Expression Regulation, Developmental Gene Expression Regulation, Enzymologic [G05.308.320] Gene Expression Regulation, Enzymologic Gene Expression Regulation, Fungal [G05.308.330] Gene Expression Regulation, Fungal Gene Expression Regulation, Neoplastic [G05.308.370] Gene Expression Regulation, Neoplastic Gene Expression Regulation, Plant [G05.308.375] Gene Expression Regulation, Plant Gene Expression Regulation, Viral [G05.308.385] Gene Expression Regulation, Viral Protein Modification, Translational [G05.308.670] Protein Modification, Translational RNA Processing, Post-Transcriptional [G05.308.700] RNA Processing, Post-Transcriptional Transcriptional Activation [G05.308.800] Transcriptional Activation Up-Regulation [G05.308.850] Up-Regulation PHENOMENA AND PROCESSES Physiological Phenomena [G07] Physiological Phenomena Pharmacological and Toxicological Phenomena [G07.690] Pharmacological and Toxicological Phenomena Pharmacological Phenomena [G07.690.773] Pharmacological Phenomena Cytoprotection [G07.690.773.500] Cytoprotection Depression, Chemical [G07.690.773.750] Depression, Chemical Dose-Response Relationship, Drug [G07.690.773.875] Dose-Response Relationship, Drug Down-Regulation [G07.690.773.937] Down-Regulation Drug Interactions [G07.690.773.968] Drug Interactions Drug Resistance [G07.690.773.984] Drug Resistance Drug Tolerance [G07.690.773.992] Drug Tolerance Stimulation, Chemical [G07.690.773.996] Stimulation, Chemical Structure-Activity Relationship [G07.690.773.997] Structure-Activity Relationship Up-Regulation [G07.690.773.998] Up-Regulation

Down-Regulation - Preferred

Concept UI	M0023902
Scope note	A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Preferred term	Down-Regulation
Entry term(s)	Down Regulation Down-Regulation (Physiology) Downregulation

Receptor Down-Regulation - Narrower

Concept UI	M0374370
Scope note	A negative regulatory process that decreases ligand-receptor interactions. Reduction in receptor binding after ligand exposure can result from the internalization of ligand-receptor complex, an increase in receptor degradation, and/or a decrease in gene expression resulting in a decrease in receptor biosynthesis.
Preferred term	Receptor Down-Regulation
Entry term(s)	Down-Regulation, Receptor