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Descriptor English: Down-Regulation
Descriptor Spanish: Regulación hacia Abajo
Descriptor Portuguese: Regulação para Baixo
Descriptor French: Régulation négative
Entry term(s): Down Regulation
Down-Regulation (Physiology)
Down-Regulation, Receptor
Downregulation
Receptor Down-Regulation
Tree number(s): G02.111.240
G05.308.200
G07.690.773.937
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015536
Scope note: A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Public MeSH Note: 2002; see Down-Regulation (Physiology) 1990-2001
History Note: 2002 (1990)
Related: Feedback, Physiological MeSH
Up-Regulation MeSH
DeCS ID: 24611
Unique ID: D015536
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/05/26
Revision Date: 2016/06/17
Down-Regulation - Preferred
Concept UI M0023902
Scope note A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Preferred term Down-Regulation
Entry term(s) Down Regulation
Down-Regulation (Physiology)
Downregulation
Receptor Down-Regulation - Narrower
Concept UI M0374370
Scope note A negative regulatory process that decreases ligand-receptor interactions. Reduction in receptor binding after ligand exposure can result from the internalization of ligand-receptor complex, an increase in receptor degradation, and/or a decrease in gene expression resulting in a decrease in receptor biosynthesis.
Preferred term Receptor Down-Regulation
Entry term(s) Down-Regulation, Receptor



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