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Descriptor English: Up-Regulation
Descriptor Spanish: Regulación hacia Arriba
Descriptor Portuguese: Regulação para Cima
Descriptor French: Régulation positive
Entry term(s): Receptor Up-Regulation
Up Regulation
Up-Regulation (Physiology)
Upregulation
Tree number(s): G02.111.905
G05.308.850
G07.690.773.998
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015854
Scope note: A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Allowable Qualifiers: DE drug effects
ES ethics
GE genetics
IM immunology
PH physiology
RE radiation effects
Public MeSH Note: 2002; see Up-Regulation (Physiology) 1990-2001
History Note: 2002 (1990)
Related: Down-Regulation MeSH
Feedback, Physiological MeSH
DeCS ID: 24907
Unique ID: D015854
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/05/26
Revision Date: 2016/06/17
Up-Regulation - Preferred
Concept UI M0024283
Scope note A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Preferred term Up-Regulation
Entry term(s) Up Regulation
Up-Regulation (Physiology)
Upregulation
Receptor Up-Regulation - Narrower
Concept UI M0374376
Scope note A positive regulatory process that increases ligand-receptor interactions. Increase in receptor binding after ligand exposure can result from receptor activation, aggregation, increase in half-life, and/or an increase in gene expression that leads to de novo receptor synthesis.
Preferred term Receptor Up-Regulation



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