DeCS

Descriptor English:

Transforming Growth Factor beta

Descriptor Spanish:

Factor de Crecimiento Transformador beta

Spanish from Spain

Descriptor	factor de crecimiento transformador beta
Entry term(s)	TGF-beta factor de crecimiento transformador de plaquetas factor de crecimiento transformador derivado del hueso factor del crecimiento transformador beta
Scope note:	Factor sintetizado en una amplia variedad de tejidos. Actúa de modo sinérgico con el TGF-alfa en la inducción de transformación fenotípica y puede actuar también como factor de crecimiento autocrino negativo. El TGF-beta tiene un papel potencial en el desarrollo embrionario, diferenciación celular, secreción hormonal y función inmunológica. El TGF-beta se encuentra muy frecuentemente como formas homodiméricas de productos genéticos distintos, TGF-beta1, TGF-beta2 o TGF-beta3. Se han aislado heterodímeros compuestos de TGF-beta1 y 2 (TGF-beta1.2) o de TGF-beta2 y 3 (TGF-beta2.3). Las proteínas TGF-beta son sintetizadas como proteínas precursoras.

Descriptor Portuguese:

Fator de Crescimento Transformador beta

Descriptor French:

Facteur de croissance transformant bêta

Entry term(s):

Bone Derived Transforming Growth Factor
Bone-Derived Transforming Growth Factor
Factor, Milk Growth
Growth Factor, Milk
Milk Growth Factor
Platelet Transforming Growth Factor
TGF-beta
TGFbeta

Tree number(s):

D12.644.276.374.687
D12.644.276.954.775
D12.776.467.374.687
D12.776.467.942.775
D23.529.374.687
D23.529.942.775

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D016212

Scope note:

A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.

Allowable Qualifiers:

AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine

Concept UI	M0024757
Scope note	A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
Preferred term	Transforming Growth Factor beta
Entry term(s)	Bone Derived Transforming Growth Factor Bone-Derived Transforming Growth Factor Factor, Milk Growth Growth Factor, Milk Milk Growth Factor Platelet Transforming Growth Factor TGF-beta TGFbeta

We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.