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Descriptor English: Ku Autoantigen
Descriptor Spanish: Autoantígeno Ku
Descriptor Portuguese: Autoantígeno Ku
Descriptor French: Autoantigène Ku
Entry term(s): Antigen, G22P1
Antigen, Ku
Antigen, Ku70
Antigen, Ku80
Autoantigen, Ku
G22P1 Antigen
Heterodimer, Ku
Ku Antigen
Ku Autoantigen, 70 kDa
Ku Autoantigen, 80 kDa
Ku Heterodimer
Ku Protein
Ku70 Antigen
Ku80 Antigen
X ray Repair Cross Complementing Protein 5
X ray Repair Cross Complementing Protein 6
X-ray Repair Cross-Complementing Protein 5
X-ray Repair Cross-Complementing Protein 6
XRCC5 Protein
XRCC6 Protein
Tree number(s): D08.811.277.040.025.159.155
D08.811.399.340.155
D12.776.157.687.493
D12.776.260.525
D12.776.660.625.625
D12.776.660.720.493
D23.050.290.625
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000072200
Scope note: An ATP-dependent DNA HELICASE that preferentially binds SINGLE-STRANDED DNA. It is a heterodimer consisting of an 80 kDa subunit (XRCC5) and 70 kDa subunit (XRCC6) that functions with DNA LIGASE IV in the repair of DOUBLE-STRANDED DNA BREAKS and V(D)J RECOMBINATION.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 4.2.99.-
Public MeSH Note: 2017; KU AUTOANTIGEN was indexed under DNA-BINDING PROTEINS and ANTIGENS, NUCLEAR 2003-2016; and under ANTIGENS, SURFACE 1986-1991 and NUCLEAR PROTEINS 1985-2003
History Note: 2017 (1986)
DeCS ID: 56468
Unique ID: D000072200
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2017/05/24
Ku Autoantigen - Preferred
Concept UI M0138075
Scope note An ATP-dependent DNA HELICASE that preferentially binds SINGLE-STRANDED DNA. It is a heterodimer consisting of an 80 kDa subunit (XRCC5) and 70 kDa subunit (XRCC6) that functions with DNA LIGASE IV in the repair of DOUBLE-STRANDED DNA BREAKS and V(D)J RECOMBINATION.
Preferred term Ku Autoantigen
Entry term(s) Antigen, G22P1
Antigen, Ku
Autoantigen, Ku
G22P1 Antigen
Heterodimer, Ku
Ku Antigen
Ku Heterodimer
Ku Protein
Ku80 Antigen - Narrower
Concept UI M0466161
Preferred term Ku80 Antigen
Entry term(s) Antigen, Ku80
Ku Autoantigen, 80 kDa
X ray Repair Cross Complementing Protein 5
X-ray Repair Cross-Complementing Protein 5
XRCC5 Protein
Ku70 Antigen - Narrower
Concept UI M0453319
Preferred term Ku70 Antigen
Entry term(s) Antigen, Ku70
Ku Autoantigen, 70 kDa
X ray Repair Cross Complementing Protein 6
X-ray Repair Cross-Complementing Protein 6
XRCC6 Protein



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