DeCS

Descriptor English:

Ku Autoantigen

Descriptor Spanish:

Autoantígeno Ku

Spanish from Spain

Descriptor	autoantígeno Ku
Entry term(s)	antígeno G22P1 antígeno Ku antígeno Ku70 antígeno Ku80 autoantígeno Ku 70 kDa autoantígeno Ku 80kDa autoantígeno Ku de 70 kDa heterodímero Ku proteína 5 de complementación cruzada de la reparación de las lesiones inducidas por los rayos X proteína 5 de reparación de complementación cruzada de rayos X proteína 5 de reparación del ADN proteína 6 de complementación cruzada de la reparación de las lesiones inducidas por los rayos X proteína 6 de reparación de complementación cruzada de rayos X proteína 6 de reparación del ADN proteína Ku proteína XRCC5 proteína XRCC6
Scope note:	ADN HELICASA dependiente de ATP que se une de forma preferente al ADN DE CADENA SIMPLE. Es un heterodímero formado por una subunidad de 80 kDa (XRCC5) y otra de 70 kDa (XRCC6) que actúa con la ADN LIGASA IV reparando las ROTURAS DEL ADN DE CADENA DOBLE y en la RECOMBINACIÓN V(D)J.

Descriptor Portuguese:

Autoantígeno Ku

Descriptor French:

Autoantigène Ku

Entry term(s):

Antigen, G22P1
Antigen, Ku
Antigen, Ku70
Antigen, Ku80
Autoantigen, Ku
G22P1 Antigen
Heterodimer, Ku
Ku Antigen
Ku Autoantigen, 70 kDa
Ku Autoantigen, 80 kDa
Ku Heterodimer
Ku Protein
Ku70 Antigen
Ku80 Antigen
X ray Repair Cross Complementing Protein 5
X ray Repair Cross Complementing Protein 6
X-ray Repair Cross-Complementing Protein 5
X-ray Repair Cross-Complementing Protein 6
XRCC5 Protein
XRCC6 Protein

Tree number(s):

D08.811.277.040.025.159.155
D08.811.399.340.155
D12.776.157.687.493
D12.776.260.525
D12.776.660.625.625
D12.776.660.720.493
D23.050.290.625

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D000072200

Scope note:

An ATP-dependent DNA HELICASE that preferentially binds SINGLE-STRANDED DNA. It is a heterodimer consisting of an 80 kDa subunit (XRCC5) and 70 kDa subunit (XRCC6) that functions with DNA LIGASE IV in the repair of DOUBLE-STRANDED DNA BREAKS and V(D)J RECOMBINATION.

Allowable Qualifiers:

AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine

Registry Number:

EC 4.2.99.-

Public MeSH Note:

2017; KU AUTOANTIGEN was indexed under DNA-BINDING PROTEINS and ANTIGENS, NUCLEAR 2003-2016; and under ANTIGENS, SURFACE 1986-1991 and NUCLEAR PROTEINS 1985-2003

Concept UI	M0138075
Scope note	An ATP-dependent DNA HELICASE that preferentially binds SINGLE-STRANDED DNA. It is a heterodimer consisting of an 80 kDa subunit (XRCC5) and 70 kDa subunit (XRCC6) that functions with DNA LIGASE IV in the repair of DOUBLE-STRANDED DNA BREAKS and V(D)J RECOMBINATION.
Preferred term	Ku Autoantigen
Entry term(s)	Antigen, G22P1 Antigen, Ku Autoantigen, Ku G22P1 Antigen Heterodimer, Ku Ku Antigen Ku Heterodimer Ku Protein

Concept UI	M0466161
Preferred term	Ku80 Antigen
Entry term(s)	Antigen, Ku80 Ku Autoantigen, 80 kDa X ray Repair Cross Complementing Protein 5 X-ray Repair Cross-Complementing Protein 5 XRCC5 Protein

Concept UI	M0453319
Preferred term	Ku70 Antigen
Entry term(s)	Antigen, Ku70 Ku Autoantigen, 70 kDa X ray Repair Cross Complementing Protein 6 X-ray Repair Cross-Complementing Protein 6 XRCC6 Protein

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